Preclinical therapies to prevent or treat fracture non-union: A systematic review.
Preclinical therapies to prevent or treat fracture non-union: A systematic review.
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预防或治疗裂缝非工会的临床前疗法：系统评价。
DOI：
10.1371/journal.pone.0201077
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Penn-Barwell JG
中科院分区：
文献类型：
--
作者：
Bennett PM;Stewart SK;Dretzke J;Bem D;Penn-Barwell JG
骨不连影响高达 10% 的骨折，并且与高发病率相关。目前没有单一有效的疗法来治疗或预防骨不连。目前，临床试验的潜在治疗方法是根据有限的动物研究结果来选择的，并没有尝试比较治疗方法之间的结果，以确定哪种治疗方法最有可能治疗骨不连。本系统评价的目的是确定临床前阶段正在研究的预防或治疗骨折不愈合的治疗方法范围。此外，通过荟萃分析，它旨在确定最有希望进入临床研究的疗法。 MEDLINE 和 Embase 检索了 2004 年 1 月 1 日至 2017 年 4 月 10 日期间评估预防或治疗骨折不愈合干预措施的对照试验。提取了有关所用模型、研究干预和结果测量的数据，并评估了偏倚风险。在已识别的 5,171 条记录中，包括 197 篇描述 204 种疗法的论文。其中，大多数仅评估一次（179/204，88%），其中壳聚糖测试最常见（6/204，3%）。模型设计、生存时间和治疗持续时间存在很大差异，但结果报告很少。这些因素以及缺乏一致使用的客观结果衡量标准阻碍了荟萃分析。这篇综述强调了当前非工会研究的可变性和糟糕的方法报告。作者呼吁就调查非结合的动物模型的标准化达成共识，并建议期刊在考虑发表动物研究时采用严格的标准。
Non-union affects up to 10% of fractures and is associated with substantial morbidity. There is currently no single effective therapy for the treatment or prevention of non-union. Potential treatments are currently selected for clinical trials based on results from limited animal studies, with no attempt to compare results between therapies to determine which have the greatest potential to treat non-union. The aim of this systematic review was to define the range of therapies under investigation at the preclinical stage for the prevention or treatment of fracture non-union. Additionally, through meta-analysis, it aimed to identify the most promising therapies for progression to clinical investigation. MEDLINE and Embase were searched from 1St January 2004 to 10th April 2017 for controlled trials evaluating an intervention to prevent or treat fracture non-union. Data regarding the model used, study intervention and outcome measures were extracted, and risk of bias assessed. Of 5,171 records identified, 197 papers describing 204 therapies were included. Of these, the majority were only evaluated once (179/204, 88%), with chitosan tested most commonly (6/204, 3%). Substantial variation existed in model design, length of survival and duration of treatment, with results poorly reported. These factors, as well as a lack of consistently used objective outcome measures, precluded meta-analysis. This review highlights the variability and poor methodological reporting of current non-union research. The authors call for a consensus on the standardisation of animal models investigating non-union, and suggest journals apply stringent criteria when considering animal work for publication.
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DOI：
10.1007/s10856-013-5091-2
发表时间：
2014-02
期刊：
Journal of materials science. Materials in medicine
影响因子：
--
作者：
Azevedo AS;Sá MJ;Fook MV;Neto PI;Sousa OB;Azevedo SS;Teixeira MW;Costa FS;Araújo AL
通讯作者：
Araújo AL
影响因子：
2.8
作者：
Daei-farshbaf, Neda;Ardeshirylajimi, Abdolreza;Norouzian, Mohsen
通讯作者：
Norouzian, Mohsen
影响因子：
5.3
作者：
Bernick, Joshua;Wang, Yufa;Nam, Diane
通讯作者：
Nam, Diane
影响因子：
4.1
作者：
Bougioukli S;Jain A;Sugiyama O;Tinsley BA;Tang AH;Tan MH;Adams DJ;Kostenuik PJ;Lieberman JR
通讯作者：
Lieberman JR
DOI：
10.1016/j.injury.2011.03.046
发表时间：
2011-06-01
影响因子：
2.5
作者：
Calori, G. M.;Mazza, E.;Tagliabue, L.
通讯作者：
Tagliabue, L.