Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits.
Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits.
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DOI：
10.1007/s10856-013-5091-2
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Araújo AL
中科院分区：
文献类型：
--
作者：
Azevedo AS;Sá MJ;Fook MV;Neto PI;Sousa OB;Azevedo SS;Teixeira MW;Costa FS;Araújo AL
本研究的目的是评价壳聚糖和β-磷酸三钙（β-TCP）单独和联合应用在兔骨再生过程中的作用。共使用了12只新西兰兔，雌雄各半，平均体重为3.0 ± 0.57 kg。将动物随机分为两个实验时间点，其中6只动物在手术后45天安乐死，6只在手术后90天安乐死。我们在每个胫骨上进行了两次截骨术。左侧胫骨用于壳聚糖（QUI）和对照组，右侧胫骨用于β-TCP单独和与壳聚糖组合（QUI+TCP）组。断层扫描评价显示组间无统计学显著差异;然而，给药组的不透射线性较高。比较描述性组织学评价发现，治疗组刺激了更明显的组织修复反应，并加速了骨修复。形态测定分析显示，与对照组相比，治疗组的骨形成具有统计学意义。
The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group.
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影响因子：
24.2
作者：
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通讯作者：
Bohner, Marc
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作者：
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通讯作者：
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