Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents.
Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents.
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DOI：
10.1021/ac202164p
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发表时间：
2011-11-15
影响因子：
7.4
通讯作者：
Wong, Season S. S.
中科院分区：
文献类型：
--
作者：
Wang, Lingyan;Luo, Jin;Shan, Shiyao;Crew, Elizabeth;Yin, Jun;Zhong, Chuan-Jian;Wallek, Brandi;Wong, Season S. S.
银纳米颗粒在可从目标液体中分离的同时起到抗菌剂的作用，这对生物液中的细菌灭活非常重要。本文报道了用湿化学法合成的银包覆磁性纳米粒子的抗菌活性分析。分析了革兰氏阳性菌(金黄色葡萄球菌和蜡状芽孢杆菌)和革兰氏阴性菌(铜绿假单胞菌、阴沟肠杆菌和大肠埃希菌)的细菌灭活情况。结果表明，银包覆磁性纳米颗粒在实现有效的细菌灭活效率方面的可行性与常规使用的银纳米颗粒相当，甚至更好。我们还检测了我们的MZF@Ag纳米颗粒对血小板样本的细菌灭活效率，证明了在输血前使用MZF@Ag纳米颗粒来灭活血小板中的细菌生长以确保血液产品安全的潜力，这也对实现有效分离、输送和靶向抗菌剂的能力具有重要意义。
The ability for silver nanoparticles to function as an antibacterial agent while being separable from the target fluids is important for bacterial inactivation in biological fluids. This report describes the analysis of the antimicrobial activities of silver-coated magnetic nanoparticles synthesized by wet chemical methods. The bacterial inactivation of several types of bacteria was analyzed, including Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and Gram-negative bacteria (Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli). The results have demonstrated the viability of the silver-coated magnetic nanoparticles for achieving effective bacterial inactivation efficiency comparable to and better than silver nanoparticles conventionally used. The bacteria inactivation efficiency of our MZF@Ag nanoparticles were also determined for blood platelets samples, demonstrating the potential of utilization in inactivating bacterial growth in platelets prior to transfusion to ensure blood product safety, which also has important implications for enabling the capability of effective separation, delivery and targeting of the antibacterial agents.
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