Constructing and deconstructing the gate theory of pain.
Constructing and deconstructing the gate theory of pain.
复制标题
DOI：
10.1016/j.pain.2013.12.010
复制
发表时间：
2014-02
期刊：
影响因子：
7.4
通讯作者：
Mendell LM
中科院分区：
文献类型：
--
作者：
Mendell LM
1965年，罗纳德梅尔扎克和帕特里克沃尔在《科学》杂志上发表了疼痛的门理论，该理论为编码皮肤感觉输入的伤害性成分提供了一种机制。该理论明确地处理了20世纪60年代的一个明显矛盾，即缺乏对强烈刺激有选择性反应的感觉神经元，以及已经确立的发现，即刺激外周神经中的小纤维才能被描述为疼痛。它结合了最近发现的突触前控制机制的突触传递从大的和小的感觉传入，这是建议“门”传入的信息取决于这些输入之间的平衡。其他重要的特征包括将感觉信息传递到前脑的脊髓神经元上的大小感觉输入的会聚，以及下行控制通路影响由门建立的偏置的能力。该模型及其描述的清晰度使这篇论文立即可见，并进行了许多尝试来测试其各种预测。尽管随后的实验和临床研究结果表明，该模型在细节上并不正确，但论文中提出的总体思路以及它们在动物和患者身上引发的实验改变了我们对疼痛机制的理解。
The Gate Theory of Pain, published by Ronald Melzack and Patrick Wall in Science in 1965, was formulated to provide a mechanism for coding the nociceptive component of cutaneous sensory input. The theory dealt explicitly with the apparent conflict in the 1960s between the paucity of sensory neurons that responded selectively to intense stimuli and the well-established finding that stimulation of the small fibers in peripheral nerves is required for the stimulus to be described as painful. It incorporated recently discovered mechanisms of presynaptic control of synaptic transmission from large and small sensory afferents which was suggested to “gate” incoming information depending on the balance between these inputs. Other important features included the convergence of small and large sensory inputs on spinal neurons that transmitted the sensory information to the forebrain as well as the ability of descending control pathways to affect the biasing established by the gate. The clarity of the model and its description gave this paper immediate visibility with numerous attempts made to test its various predictions. Although subsequent experiments and clinical findings have made clear that the model is not correct in detail, the general ideas put forth in the paper and the experiments they prompted in both animals and patients have transformed our understanding of pain mechanisms.
登录
查看更多内容
影响因子：
2.9
作者：
BASBAUM, AI;WALL, PD
通讯作者：
WALL, PD
影响因子：
9.9
作者：
DYCK, PJ;LAMBERT, EH;OBRIEN, PC
通讯作者：
OBRIEN, PC
影响因子：
5.5
作者：
BURGESS, PR;PERL, ER
通讯作者：
PERL, ER
影响因子：
2.5
作者：
HODGE, CJ
通讯作者：
HODGE, CJ
影响因子：
5.5
作者：
HUNT, CC;MCINTYRE, AK
通讯作者：
MCINTYRE, AK