Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells.
Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells.
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DOI：
10.1002/eji.200838186
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发表时间：
2008-10
影响因子：
5.4
通讯作者：
Udomsangpetch, Rachanee
中科院分区：
文献类型：
--
作者：
Jangpatarapongsa, Kulachart;Chootong, Patchanee;Sattabongkot, Jetsumon;Chotivanich, Kesinee;Sirichaisinthop, Jeeraphat;Tungpradabkul, Sumalee;Hisaeda, Hajime;Troye-Blomberg, Marita;Cui, Liwang;Udomsangpetch, Rachanee
间日疟原虫感染诱导的免疫导致记忆 T 细胞在后续感染过程中招募和激活。在这里，我们研究了间日疟原虫感染过程中调节性 T 细胞 (Treg) 与宿主免疫反应协调的作用。我们的结果显示，与初次感染或免疫对照相比，急性间日疟原虫感染患者中 FOXP3+ Treg、分泌 I 型 Treg (Tr1) 的 IL-10 的百分比和 IL-10 水平显着增加。 Treg 群体的同时增加也可以在体外使用来自幼稚对照的 PBMC 进行复制，该对照用从间日疟原虫感染的红细胞中提取的粗抗原进行刺激。急性间日疟原虫感染与 DC 数量显着减少相关，表明间日疟原虫感染期间存在普遍的免疫抑制。然而，与恶性疟原虫感染不同，我们发现急性间日疟原虫患者中的髓样 DC (MDC) 和类浆细胞 (PDC) 之间的比率显着低于初次感染者和免疫对照者。此外，PDC 的减少可能是间日疟原虫感染期间抗体反应较差的部分原因。综上所述，这些结果表明间日疟原虫与 DC 相互作用，从而改变 MDC/PDC 比率，从而可能导致 Treg 激活和 IL-10 释放。
Immunity induced by Plasmodium vivax infections leads to memory T cell recruitment and activation during subsequent infections. Here, we investigated the role of regulator T cells (Treg) in coordination with the host immune response during P. vivax infection. Our results showed a significant increase in the percentage of FOXP3+ Treg, IL-10 secreting Type I Treg (Tr1) and IL-10 levels in patients with acute P. vivax infection as compared to those found in either naïve or immune controls. The concurrent increase in the Treg population could also be reproduced in vitro using PBMC from naïve controls stimulated with crude antigens extracted from P. vivax-infected red blood cells. Acute P. vivax infections were associated with a significant decrease in the numbers of DC, indicating a general immunosuppression during P.vivax infections. However, unlike P. falciparum infections, we found that the ratio between myeloid DC (MDC) and plamacytoid (PDC) was significantly lower in acute P. vivax patients than that of naïve and immune controls. Moreover, the reduction of PDC may be partly responsible for the poor antibody responses during P. vivax infections. Taken together, these results suggest that P. vivax parasites interact with DC, which alters MDC/PDC ratio that potentially leads to Treg activation and IL-10 release.
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CD127表达与FOXP3和人类CD4+ T Reg细胞的抑制功能成反比。
DOI：
10.1084/jem.20060772
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
Rissoan, MC;Soumelis, V;Liu, YJ
通讯作者：
Liu, YJ
影响因子：
6.4
作者：
Prakash, D.;Fesel, Constantin;Pied, Sylviane
通讯作者：
Pied, Sylviane
影响因子：
82.9
作者：
Hisaeda, H;Maekawa, Y;Yasutomo, K
通讯作者：
Yasutomo, K
影响因子：
32.4
作者：
Jego, G;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J