Early temperamental fearfulness and the developmental trajectory of error-related brain activity.
Early temperamental fearfulness and the developmental trajectory of error-related brain activity.
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DOI：
10.1002/dev.21605
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发表时间：
2018-03
影响因子：
2.2
通讯作者：
Klein DN
中科院分区：
文献类型：
--
作者：
Meyer A;Hajcak G;Torpey-Newman D;Kujawa A;Olino TM;Dyson M;Klein DN
错误相关负性（errerror -related negative， ERN）是当个体犯错误时发生的事件相关电位波形的负偏转，ERN的增加被认为是焦虑的生物标志物。然而，先前的研究表明，害怕的孩子的特征是一个较小的ERN。我们提出，这可能反映了焦虑在发展过程中不断变化的现象。在目前的研究中，我们使用纵向受试者内设计来调查这种可能性。我们在271名儿童3岁时完成了恐惧的观察测量，然后在儿童6岁和9岁时测量了ERN。恐惧儿童在6岁时的特征是ERN下降；到9岁时，同样是那些在3岁时感到恐惧的孩子，他们的nn增加了——这种模式与焦虑的青少年和成年人非常相似。
The error-related negativity (ERN) is a negative deflection in the event-related potential waveform that occurs when an individual makes a mistake, and an increased ERN has been proposed as a biomarker for anxiety. However, previous work suggests that fearful children are characterized by a smaller ERN. We have proposed that this may reflect the changing phenomenology of anxiety across development. In the current study, we investigate this possibility using a longitudinal within- subject design. In 271 children, we completed observational measures of fear when the children were 3 years old, and then measured the ERN when the children were 6 and 9 years-old. Fearful children were characterized by a decreased ERN when they were 6-years-old; by age 9, the same children who were fearful at age 3 had increased ERNs—a pattern that closely resembles that of anxious adolescents and adults.
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DOI：
10.1016/j.jaac.2013.09.017
发表时间：
2014-01
影响因子：
13.3
作者：
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通讯作者：
Costello, E. Jane
影响因子：
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作者：
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DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
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作者：
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