Diet and blood coagulation factor VII—a key protein in arterial thrombosis

Diet and blood coagulation factor VII—a key protein in arterial thrombosis
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饮食和凝血因子 VII——动脉血栓形成的关键蛋白

DOI:
--
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发表时间:
1998
影响因子:
4.7
通讯作者:
Jørgen Jespersen
Jørgen Jespersen
中科院分区:
医学3区
文献类型:
--
作者:
P. Marckmann;E. Bladbjerg;Jørgen Jespersen

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止血系统对维持生命至关重要。止血系统保护人在伤口损伤后免于失血,并且还形成了许多组织修复过程的基础,这些组织修复过程被认为是在血管床内持续进行的,如Tage Astrup在四十多年前最初提出的(Astrup,1956)。止血系统有助于动脉粥样硬化形成并控制血管内血栓形成,因此在冠心病(CHD),特别是急性缺血性事件(心肌梗死、不稳定型心绞痛和猝死)和缺血性卒中的发生中起重要作用(Fuster et al,1992 a,1992 b; Falk & Fernain-Ortiz,1995)。这些疾病是工业化国家的主要死因。因此,最感兴趣的是深入了解止血系统及其可能通过内部和外部因素进行的修改。这些知识可以为合理预防心脑血管疾病铺平道路。本文综述了饮食对凝血因子VII(FVII)的影响,并探讨了FVII的饮食调控机制。饮食对FVII和其他重要的止血因子的影响在最近的几篇综述中进行了讨论,感兴趣的读者可以参考这些综述进行额外的阅读(Marckmann & Jespersen,1994,1996; Marckmann,1995; Mennen et al,1996;米勒,1996; Vorster et al,1997; Yahia & Sanders,1997)。
The haemostatic system is essential for the preservation of life. The haemostatic system protects man from exsanguination after wound injuries and also forms the basis for the numerous tissue repair processes that are believed to be constantly ongoing within the vascular bed as initially proposed by Tage Astrup more than four decades ago (Astrup, 1956). The haemostatic system contributes to atherogenesis and controls intravascular thrombus formation, and thus plays an important role in the development of coronary heart disease (CHD), notably acute ischaemic events (myocardial infarction, unstable angina pectoris, and sudden death), and ischaemic stroke (Fuster et al, 1992a, 1992b; Falk & FernaÂndez-Ortiz, 1995). These diseases are dominant causes of death in industrialised countries. Accordingly, it is of utmost interest to gain insight into the haemostatic system and its possible modi®cation by internal and external factors. Such knowledge could pave the way for rational prevention of cardioand cerebrovascular disease. The present review describes how diet affects one key protein of the haemostatic systemÐ blood coagulation factor VII (FVII)Ðand also discusses the possible mechanisms underlying the dietary control of FVII. The impact of diet on FVII and other important haemostatic factors has been discussed in several other recent reviews to which interested readers are referred for additional reading (Marckmann & Jespersen, 1994, 1996; Marckmann, 1995; Mennen et al, 1996; Miller, 1996; Vorster et al, 1997; Yahia & Sanders, 1997).
DOI: 10.1021/bi00107a001
发表时间: 1991-10-29
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
DAVIE, EW;FUJIKAWA, K;KISIEL, W
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DOI: --
发表时间: 1993-12
期刊: The Journal of laboratory and clinical medicine
影响因子: --
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DOI: 10.1016/0021-9150(91)90167-2
发表时间: 1991-12-01
期刊: ATHEROSCLEROSIS
影响因子: 5.3
作者:
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通讯作者: SZKLO, M
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DOI: --
发表时间: 1992
影响因子: 3.6
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人类凝血激活的决定因素。
DOI: 10.1159/000217244
发表时间: 1996
期刊: Haemostasis
影响因子: --
作者:
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通讯作者: Rosenberg,RD