Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity.
Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity.
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DOI：
10.1155/2010/759234
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发表时间：
2010
影响因子：
2.8
通讯作者：
Van Cauter E
中科院分区：
文献类型：
--
作者：
Balbo M;Leproult R;Van Cauter E
皮质醇分泌的日节律相对稳定，主要受生物钟的影响。然而，其他几个因素影响下丘脑-垂体-肾上腺（HPA）轴的活动。睡眠对下丘脑-垂体-肾上腺轴活动有适度但可明显检测到的调节作用。睡眠开始对皮质醇分泌产生抑制作用，而觉醒和睡眠抵消伴随着皮质醇刺激。在清醒期间，皮质醇分泌爆发和中枢唤醒指数之间的关联也被检测到。睡眠时间的突然变化会导致每日皮质醇节律的深刻破坏，而睡眠剥夺和/或睡眠质量降低似乎会导致轴的适度但功能重要的激活。HPA过度活跃与代谢、认知和精神障碍明显相关，并且可能涉及睡眠障碍与肥胖、糖尿病和认知功能障碍风险之间的充分记录的关联。几种临床综合征，如失眠症、抑郁症、库欣综合征、睡眠呼吸障碍（SDB），表现为HPA亢进、睡眠障碍、精神和代谢障碍。需要进一步的研究来描述睡眠和HPA轴活动之间的功能联系，以充分了解这些综合征的病理生理学，并制定适当的预防和治疗策略。
The daily rhythm of cortisol secretion is relatively stable and primarily under the influence of the circadian clock. Nevertheless, several other factors affect hypothalamo-pituitary-adrenal (HPA) axis activity. Sleep has modest but clearly detectable modulatory effects on HPA axis activity. Sleep onset exerts an inhibitory effect on cortisol secretion while awakenings and sleep offset are accompanied by cortisol stimulation. During waking, an association between cortisol secretory bursts and indices of central arousal has also been detected. Abrupt shifts of the sleep period induce a profound disruption in the daily cortisol rhythm, while sleep deprivation and/or reduced sleep quality seem to result in a modest but functionally important activation of the axis. HPA hyperactivity is clearly associated with metabolic, cognitive and psychiatric disorders and could be involved in the well-documented associations between sleep disturbances and the risk of obesity, diabetes and cognitive dysfunction. Several clinical syndromes, such as insomnia, depression, Cushing's syndrome, sleep disordered breathing (SDB) display HPA hyperactivity, disturbed sleep, psychiatric and metabolic impairments. Further research to delineate the functional links between sleep and HPA axis activity is needed to fully understand the pathophysiology of these syndromes and to develop adequate strategies of prevention and treatment.
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影响因子：
3.7
作者：
BORN, J;MUTH, S;FEHM, HL
通讯作者：
FEHM, HL
影响因子：
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作者：
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影响因子：
64.5
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DOI：
10.1152/ajpendo.00780.2007
发表时间：
2008-08-01
影响因子：
5.1
作者：
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通讯作者：
Zanella, Maria Teresa
影响因子：
6.6
作者：
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通讯作者：
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