The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.
The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.
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DOI:
10.1016/j.toxicon.2012.03.010
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发表时间:
2012-09-15
期刊:
影响因子:
2.8
通讯作者:
Poux, Sylvain
中科院分区:
文献类型:
--
作者:
Jungo, Florence;Bougueleret, Lydie;Xenarios, Ioannis;Poux, Sylvain
Animal toxins are of interest to a wide range of scientists, due to their numerous applications in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser extent the development of new performing tools in transcriptomics and proteomics, has led to an increase in toxin discovery. In this context, providing publicly available data on animal toxins has become essential. The UniProtKB/Swiss-Prot Tox-Prot program (http://www.uniprot.org/program/Toxins) plays a crucial role by providing such an access to venom protein sequences and functions from all venomous species. This program has up to now curated more than 5’000 venom proteins to the high-quality standards of UniProtKB/Swiss-Prot (release 2012_02). Proteins targeted by these toxins are also available in the knowledgebase. This paper describes in details the type of information provided by UniProtKB/Swiss-Prot for toxins, as well as the structured format of the knowledgebase.
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