The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.

The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.
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DOI:
10.1016/j.toxicon.2012.03.010
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发表时间:
2012-09-15
期刊:
影响因子:
2.8
通讯作者:
Poux, Sylvain
Poux, Sylvain
中科院分区:
医学4区
文献类型:
--
作者:
Jungo, Florence;Bougueleret, Lydie;Xenarios, Ioannis;Poux, Sylvain

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动物毒素在药理学、神经学、血液学、医学和药物研究中有着广泛的应用,因此引起了广泛的科学家的兴趣。这一点,以及在较小程度上转录组学和蛋白质组学中新的执行工具的发展,导致了毒素发现的增加。在这方面,提供关于动物毒素的公开数据已变得至关重要。UniProtKB/Swiss-Prot Tox-Prot程序(http://www.uniprot.org/program/Toxins)通过提供对来自所有有毒物种的毒液蛋白质序列和功能的这种访问而发挥关键作用。到目前为止,该计划已经根据UniProtKB/Swiss-Prot的高质量标准(发布2012_02)策划了5,000多种毒液蛋白。这些毒素所针对的蛋白质也可在知识库中找到。本文详细介绍了UniProtKB/Swiss-Prot提供的毒素信息类型以及知识库的结构化格式。
Animal toxins are of interest to a wide range of scientists, due to their numerous applications in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser extent the development of new performing tools in transcriptomics and proteomics, has led to an increase in toxin discovery. In this context, providing publicly available data on animal toxins has become essential. The UniProtKB/Swiss-Prot Tox-Prot program (http://www.uniprot.org/program/Toxins) plays a crucial role by providing such an access to venom protein sequences and functions from all venomous species. This program has up to now curated more than 5’000 venom proteins to the high-quality standards of UniProtKB/Swiss-Prot (release 2012_02). Proteins targeted by these toxins are also available in the knowledgebase. This paper describes in details the type of information provided by UniProtKB/Swiss-Prot for toxins, as well as the structured format of the knowledgebase.
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