Immune Cell Activation in Obesity and Cardiovascular Disease.
Immune Cell Activation in Obesity and Cardiovascular Disease.
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DOI：
10.1007/s11906-022-01222-4
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发表时间：
2022-12
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
在这篇综述中，我们侧重于肥胖和心血管疾病中免疫细胞的激活，强调动脉粥样硬化、非缺血性心脏病、高血压和感染性疾病个体中存在的特定免疫细胞微环境。肥胖和心血管疾病密切相关，通常以炎症和一系列代谢并发症为特征。来自单细胞分析的令人信服的证据表明，肥胖的脂肪组织是炎症性的，几乎被所有免疫细胞群渗透。这种炎症组织状态如何导致更多的系统性疾病，如心血管疾病和传染病，人们还不太清楚。然而，目前的研究表明，脂肪组织免疫环境的变化会影响个人对抗流感和SARS-CoV2等疾病的能力。肥胖症在全球范围内正变得越来越普遍，并经常与2型糖尿病和心脏病有关。炎症状态的增加是导致这种联系的主要原因。在这些疾病状态下，广泛的慢性炎症伴随着先天性和获得性免疫细胞激活的增加。尖锐地说，这些免疫细胞的变化是有益的，因为随着炎症的增加，它们保持了体内平衡。然而，持续性炎症随后会损害全身的组织和器官。未来的研究旨在了解受肥胖影响的每个组织间隔中独特的免疫细胞群，可能具有治疗应用的潜力。
In this review, we focus on immune cell activation in obesity and cardiovascular disease, highlighting specific immune cell microenvironments present in individuals with atherosclerosis, non-ischemic heart disease, hypertension, and infectious diseases. Obesity and cardiovascular disease are intimately linked and often characterized by inflammation and a cluster of metabolic complications. Compelling evidence from single-cell analysis suggests that obese adipose tissue is inflammatory and infiltrated by almost all immune cell populations. How this inflammatory tissue state contributes to more systemic conditions such as cardiovascular and infectious disease is less well understood. However, current research suggests that changes in the adipose tissue immune environment impact an individual’s ability to combat illnesses such as influenza and SARS-CoV2. Obesity is becoming increasingly prevalent globally and is often associated with type 2 diabetes and heart disease. An increased inflammatory state is a major contributor to this association. Widespread chronic inflammation in these disease states is accompanied by an increase in both innate and adaptive immune cell activation. Acutely, these immune cell changes are beneficial as they sustain homeostasis as inflammation increases. However, persistent inflammation subsequently damages tissues and organs throughout the body. Future studies aimed at understanding the unique immune cell populations in each tissue compartment impacted by obesity may hold potential for therapeutic applications.
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影响因子：
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