Recall of Genomic Testing Results Among Patients with Cancer.
Recall of Genomic Testing Results Among Patients with Cancer.
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DOI：
10.1002/onco.13928
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Gray SW
中科院分区：
文献类型：
--
作者：
Wing SE;Hu H;Lopez L;Solomon I;Shen J;Raquel C;Sur M;Chao J;Cristea M;Fakih M;Mortimer J;Pal S;Reckamp K;Yuan Y;Gray SW
体细胞和生殖系DNA的基因组检测已经改变了癌症护理。然而，患者的遗传知识不足可能会影响护理和健康结果。鉴于基因组检测的兴起，我们试图了解患者对其基因检测结果的了解。我们在一家综合性癌症中心对85名患者进行了一项基于调查的研究。我们将自我报告的回忆（a）进行了体细胞/生殖细胞检测和（B）他们的特定体细胞/生殖细胞结果与病历中记录的基因组检测结果进行了比较。大约30%的患者不记得有过检测。在那些回忆起进行检测的患者中，44%的致病性/可能致病性生殖系突变患者和57%的报告了体细胞改变的患者没有准确地回忆起他们的特定基因或变异水平结果。鉴于患者对基因组检测的回忆存在显著的知识差距，迫切需要改善患者导向的教育和结果反馈策略。考虑到癌症治疗中基因组检测的增加，本研究旨在更好地了解患者对其基因检测结果的了解。
Genomic testing of somatic and germline DNA has transformed cancer care. However, low genetic knowledge among patients may compromise care and health outcomes. Given the rise in genomic testing, we sought to understand patients’ knowledge of their genetic test results. We conducted a survey‐based study with 85 patients at a comprehensive cancer center. We compared self‐reported recall of (a) having had somatic/germline testing and (b) their specific somatic/germline results to the genomic test results documented in the medical record. Approximately 30% of patients did not recall having had testing. Of those who recalled having testing, 44% of patients with pathogenic/likely pathogenic germline mutations and 57% of patients with reported somatic alterations did not accurately recall their specific gene or variant‐level results. Given significant knowledge gaps in patients’ recall of genomic testing, there is a critical need to improve patient‐directed education and return‐of‐results strategies. Considering the increase in genomic testing for cancer care, this study aimed to better understand patients’ knowledge of their genetic test results.
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影响因子：
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作者：
Langer MM;Roche MI;Brewer NT;Berg JS;Khan CM;Leos C;Moore E;Brown M;Rini C
通讯作者：
Rini C
影响因子：
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作者：
Gray, Stacy W.;Hicks-Courant, Katherine;Weeks, Jane C.
通讯作者：
Weeks, Jane C.
影响因子：
2.1
作者：
Matthews, AK;Cummings, S;Olopade, OI
通讯作者：
Olopade, OI
影响因子：
6.2
作者：
Blanchette, Phillip S.;Spreafico, Anna;Siu, Lillian L.
通讯作者：
Siu, Lillian L.
影响因子：
4.7
作者：
Lacour, Robin A.;Daniels, Molly S.;Lu, Karen H.
通讯作者：
Lu, Karen H.