Nicotine patch vs. nicotine lozenge for smoking cessation: an effectiveness trial coordinated by the Community Clinical Oncology Program.
Nicotine patch vs. nicotine lozenge for smoking cessation: an effectiveness trial coordinated by the Community Clinical Oncology Program.
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DOI：
10.1016/j.drugalcdep.2009.11.001
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Reynolds P
中科院分区：
文献类型：
--
作者：
Schnoll RA;Martinez E;Tatum KL;Glass M;Bernath A;Ferris D;Reynolds P
尼古丁替代疗法可有效治疗尼古丁依赖。然而，有限的数据存在不同的NRT的好处和治疗结果的预测。本研究比较了经皮尼古丁与尼古丁含片戒烟的有效性，并确定了治疗反应的预测因素。在参加国家癌症研究所社区临床肿瘤学项目的12个医疗点进行了一项随机、开放标签的有效性试验。样本包括642名寻求治疗的吸烟者，随机接受12周的经皮尼古丁或尼古丁含片治疗。在基线时评估吸烟者特征，并在治疗结束（EOT）和6个月随访时评估经呼吸一氧化碳（CO）证实的24小时点戒烟率。在EOT（24.3% vs. 18.7%，p = .10）和6个月（15.6% vs. 10.9%，p = .10）时，经皮尼古丁戒烟率有高于尼古丁含片的趋势。EOT戒烟率的logistic回归模型显示，首选经皮尼古丁、对吸烟线索无反应、不使用尼古丁缓解痛苦或刺激认知功能的吸烟者，经皮尼古丁的戒烟率较高。6个月戒烟率的logistic回归模型显示，首选透皮尼古丁的吸烟者对透皮尼古丁的戒烟率较高，使用尼古丁缓解痛苦或刺激认知过程的吸烟者对尼古丁含片的戒烟率较低。对于喜欢透皮尼古丁且不吸烟的吸烟者来说，透皮尼古丁可能比尼古丁含片更有效，以减轻情绪困扰或刺激认知功能。
Nicotine replacement therapies are efficacious for treating nicotine dependence. However, limited data exist on benefits of different NRTs and predictors of treatment outcome. This study compared the effectiveness of transdermal nicotine vs. nicotine lozenge for smoking cessation and identified predictors of treatment response. A randomized, open-label effectiveness trial was conducted at twelve medical sites participating in the National Cancer Institute's Community Clinical Oncology Program. The sample consisted of 642 treatment-seeking smokers randomized to twelve weeks of transdermal nicotine or nicotine lozenge. Smoker characteristics were assessed at baseline, and 24-hour point prevalence abstinence confirmed with breath carbon monoxide (CO) was evaluated at end of treatment (EOT) and at a 6-month follow-up. There was a trend for higher quit rates for transdermal nicotine vs. nicotine lozenge at EOT (24.3% vs. 18.7%, p = .10) and 6-months (15.6% vs. 10.9%, p = .10). A logistic regression model of EOT quit rates showed smokers who preferred transdermal nicotine, were not reactive to smoking cues, and did not use nicotine to alleviate distress or stimulate cognitive function had higher quit rates on transdermal nicotine. A logistic regression model of 6-month quit rates showed smokers who preferred transdermal nicotine had higher quit rates on transdermal nicotine, and smokers who used nicotine to alleviate distress or stimulate cognitive processes had lower quit rates on nicotine lozenge. Transdermal nicotine may be more effective than nicotine lozenge for smokers who prefer transdermal nicotine and do not smoke to alleviate emotional distress or stimulate cognitive function.
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影响因子：
39.2
作者：
Lerman, C;Kaufmann, V;Benowitz, N
通讯作者：
Benowitz, N
影响因子：
4.2
作者：
Lerman, C;Caporaso, N;Shields, PG
通讯作者：
Shields, PG
影响因子：
5.9
作者：
Waters, AJ;Shiffman, S;Balabanis, MH
通讯作者：
Balabanis, MH
影响因子：
4.4
作者：
Lerman, C;Audrain, J;Caporaso, N
通讯作者：
Caporaso, N
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC