Impact of pollution, climate, and sociodemographic factors on spatiotemporal dynamics of seasonal respiratory viruses.

Impact of pollution, climate, and sociodemographic factors on spatiotemporal dynamics of seasonal respiratory viruses.
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DOI:
10.1111/j.1752-8062.2010.00257.x
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发表时间:
2011-02
期刊:
Clinical and translational science
影响因子:
--
通讯作者:
Hartert T
Hartert T
中科院分区:
其他
文献类型:
--
作者:
Sloan C;Moore ML;Hartert T

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季节性病毒是温带地区发病和死亡的主要原因。流感、呼吸道合胞病毒(RSV)和人鼻病毒(HRV)等病毒通过重大流行病和较小的年度流行病,导致大多数感染者失去学校和工作日,对免疫功能低下者造成更严重的并发症。这些病毒表现出严格季节性的原因包括但不限于寒冷天气和湿度对病毒颗粒、人体生理和人类行为的影响。每一项的相对重要性取决于正在探索的地理规模以及个别地区和时间段。理论数学还表明,气候变化可能不是强烈季节周期的唯一原因,但这些也基于与免疫和抗原变异的自然周期的周期性共振,以及通过运输网络在全国范围内的同步。季节性调查将有助于了解疾病传播,从而制定有效的预防策略。作者对季节性病毒的文献、其在人群中的年度传播以及减少或增强其季节性传播的因素进行了综述。他们还为有针对性的干预措施提供建议,以减少季节性病毒造成的疾病负担。
Seasonal viruses present a major cause of morbidity and mortality in temperate climates. Through major pandemics and smaller annual epidemics, viruses such as influenza, respiratory syncytial virus (RSV) and human rhinovirus (HRV) result in lost school and work days for most that are infected and more serious complications for the immunocompromised. The reasons for these viruses showing strict seasonality include but are not limited to the influence of cold weather and humidity on virus particles, human physiology, and human behavior. The relative importance of each is dependent on what geographic scale is being explored as well as the individual region and time period. Theoretical mathematics has also revealed that climatic changes are likely not the only reasons for strong seasonal cycles, but these are also based in periodic resonance with the natural cycles of immunity and antigenic variance, as well as nation-wide synchrony through transportation networks.; Investigations of seasonality will aid in understanding disease transmission, and thereby effective prevention strategies. The authors present a review of the literature on seasonal viruses, their annual diffusion through populations, and factors that reduce or enhance their seasonal spread. They also offer suggestions for targeted interventions to reduce the disease burden from seasonal viruses.
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