The imprinted gene DIO3 is a candidate gene for litter size in pigs.
The imprinted gene DIO3 is a candidate gene for litter size in pigs.
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DOI：
10.1371/journal.pone.0031825
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Bovenhuis H
中科院分区：
文献类型：
--
作者：
Coster A;Madsen O;Heuven HC;Dibbits B;Groenen MA;van Arendonk JA;Bovenhuis H
基因组印记是一种重要的表观遗传现象，它可以通过一个基因的两个杂合体之间的差异在表型水平上进行检测。印记基因在胎盘和胚胎的发育中都很重要，我们假设印记基因可能与女性生育特征有关。因此，我们在两个商品猪群体中进行了与雌性生育性状相关的印记基因的关联研究。为此目的，在15个进化保守的印记区域的309个SNPs基因分型689和1050头猪从两个猪群体。一个单一的SNP关联研究被用来检测加性，显性和印记效应相关的四个繁殖性状：仔猪出生总数，仔猪出生活仔数，仔猪出生的总重量和仔猪出生活仔的总重量。几个SNP表现出显著的加性和显性效应，一个SNP表现出显著的印记效应。具有显著印记效应的SNP与DIO3密切相关，DIO3是一种参与甲状腺代谢的基因。该SNP的印记效应解释了约1.6%的表型方差，相当于约15.5%的加性遗传方差。在另一个群体中，该QTL的印记效应不显著（），但与第一个群体中的效应相似。本研究结果表明，印记基因DIO3与猪雌性生育性状之间可能存在关联。
Genomic imprinting is an important epigenetic phenomenon, which on the phenotypic level can be detected by the difference between the two heterozygote classes of a gene. Imprinted genes are important in both the development of the placenta and the embryo, and we hypothesized that imprinted genes might be involved in female fertility traits. We therefore performed an association study for imprinted genes related to female fertility traits in two commercial pig populations. For this purpose, 309 SNPs in fifteen evolutionary conserved imprinted regions were genotyped on 689 and 1050 pigs from the two pig populations. A single SNP association study was used to detect additive, dominant and imprinting effects related to four reproduction traits; total number of piglets born, the number of piglets born alive, the total weight of the piglets born and the total weight of the piglets born alive. Several SNPs showed significant () additive and dominant effects and one SNP showed a significant imprinting effect. The SNP with a significant imprinting effect is closely linked to DIO3, a gene involved in thyroid metabolism. The imprinting effect of this SNP explained approximately 1.6% of the phenotypic variance, which corresponded to approximately 15.5% of the additive genetic variance. In the other population, the imprinting effect of this QTL was not significant (), but had a similar effect as in the first population. The results of this study indicate a possible association between the imprinted gene DIO3 and female fertility traits in pigs.
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影响因子：
56.9
作者：
Gregg, Christopher;Zhang, Jiangwen;Dulac, Catherine
通讯作者：
Dulac, Catherine
影响因子：
56.9
作者：
Gregg, Christopher;Zhang, Jiangwen;Dulac, Catherine
通讯作者：
Dulac, Catherine
影响因子：
7.5
作者：
Edwards, Carol A.;Ferguson-Smith, Anne C.
通讯作者：
Ferguson-Smith, Anne C.
DOI：
10.1073/pnas.140216397
发表时间：
2000-07-05
影响因子：
11.1
作者：
de Koning, DJ;Rattink, AP;Groenen, MAM
通讯作者：
Groenen, MAM
影响因子：
4.8
作者：
Hernandez, A;Fiering, S;St Germain, D
通讯作者：
St Germain, D