Frontotemporal anatomical connectivity and working-relational memory performance predict everyday functioning in schizophrenia.
Frontotemporal anatomical connectivity and working-relational memory performance predict everyday functioning in schizophrenia.
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DOI：
10.1111/j.1469-8986.2012.01448.x
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发表时间：
2012-10
期刊：
影响因子：
3.7
通讯作者：
Tesche CD
中科院分区：
文献类型：
--
作者：
Hanlon FM;Houck JM;Klimaj SD;Caprihan A;Mayer AR;Weisend MP;Bustillo JR;Hamilton DA;Tesche CD
在精神分裂症 (SP) 患者中发现海马（关系记忆）和前额皮质（PFC；工作记忆）损伤，可能是由于结构之间的连接功能失调所致。描述钩束各向异性分数 (FA) 减少的神经解剖学研究支持了这一观点。通过检查额颞叶解剖连接（钩束 FA）和 PFC-海马记忆及其彼此之间的关系和日常功能，研究了 SP 的脱节假说。 PFC-海马记忆通过两项工作关系记忆任务进行检查：横向模式和虚拟莫里斯水任务。与健康志愿者相比，SP 在两项任务上均表现出缺陷，并且双侧钩束的 FA 较低。额颞叶解剖连接性较低与工作关系记忆表现较低有关，两者都预示着日常功能较差。
Hippocampal (relational memory) and prefrontal cortex (PFC; working memory) impairments have been found in patients with schizophrenia (SP), possibly due to a dysfunctional connection between structures. Neuroanatomical studies that describe reduced fractional anisotropy (FA) in the uncinate fasciculus support this idea. The dysconnection hypothesis in SP was investigated by examining fronto-temporal anatomical connectivity (uncinate fasciculus FA) and PFC-hippocampal memory and their relationship with each other and everyday functioning. PFC-hippocampal memory was examined with two working-relational memory tasks: transverse patterning and virtual Morris water task. SP exhibited a performance deficit on both tasks and had lower FA in bilateral uncinate fasciculus than healthy volunteers. Lower fronto-temporal anatomical connectivity was related to lower working-relational memory performance, and both predicted worse everyday functioning.
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