Rats tested after a washout period from sub-chronic PCP administration exhibited impaired performance in the 5-Choice Continuous Performance Test (5C-CPT) when the attentional load was increased.
Rats tested after a washout period from sub-chronic PCP administration exhibited impaired performance in the 5-Choice Continuous Performance Test (5C-CPT) when the attentional load was increased.
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DOI：
10.1016/j.neuropharm.2011.04.024
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发表时间：
2012-03
影响因子：
4.7
通讯作者：
Neill JC
中科院分区：
文献类型：
--
作者：
Barnes SA;Young JW;Neill JC
有充分的证据表明，精神分裂症患者在各种认知领域表现出功能障碍，包括注意力/警觉性，如在无数连续表现测试（CPTs）中的表现受损。NMDA受体拮抗剂提供了一种动物认知障碍的药理学模型。因此，我们研究了亚慢性PCP治疗方案（5.0 mg/kg 7天，每天两次）在最近开发的啮齿动物警觉性测试中的作用，即5选择-连续表现测试（5C-CPT）。在至少7天的洗脱期后，我们评估了该方案对基线表现和注意力负荷增加时的影响。亚慢性pcp治疗损害了5C-CPT的表现，其方式与精神分裂症患者的警觉性受损一致，命中率降低，信号敏感性受损。这些影响只有在参数操作后性能受到挑战时才会显现出来。这些数据表明，在临床前任务中，亚慢性PCP治疗后的注意力/警觉性对干扰很敏感，这可能表明与人类警觉性任务的相似性增加。虽然pcp引起的注意力缺陷不如其他领域的缺陷那么严重，但这些数据提供了证据，表明这种药理学模型可以影响多个认知领域，并可能有助于评估精神分裂症的推定认知治疗方法。
It is well documented that schizophrenia patients exhibit dysfunction in various cognitive domains, including attention/vigilance, as demonstrated by impaired performance in the myriad of continuous performance tests (CPTs). NMDA receptor antagonists provide a pharmacological model in animals of the cognitive disruption presented in the disorder. We therefore examined the effects of a sub-chronic PCP treatment regimen (5.0 mg/kg 7-days bi-daily) in the recently developed rodent test of vigilance, the 5 Choice-Continuous Performance Test (5C-CPT). We assessed the effects of this regimen after at least a 7-day washout period on both baseline performance and when the attentional load was increased. Sub-chronic PCP-treatment impaired 5C-CPT performance in a manner consistent with impaired vigilance in patients with schizophrenia, with reduced hit rate and impaired signal sensitivity. These effects were only evident when performance was challenged following parameter manipulations. These data demonstrate that attention/vigilance is sensitive to disruption following sub-chronic PCP treatment in a pre-clinical task that may demonstrate increased analogy to human vigilance tasks. Although the PCP-induced attentional deficits are not as large as those deficits observed in other domains, these data provide evidence that this pharmacological model can affect multiple cognitive domains and may be useful for assessing putative pro-cognitive therapeutics for schizophrenia.
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