Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectives.
Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectives.
复制标题
DOI：
10.1038/jp.2008.130
复制
发表时间：
2009-01
影响因子：
2.9
通讯作者：
Zeller, J. M.
中科院分区：
文献类型：
--
作者：
Rodriguez, N. A.;Meier, P. P.;Groer, M. W.;Zeller, J. M.
成人研究表明，口咽途径可用于有效和安全地给药干扰素-α（一种免疫细胞来源的细胞因子），患者不能耐受其肠外给药。其机制似乎是细胞因子对口咽相关淋巴组织系统的刺激作用。自己母亲的初乳（OMC）富含细胞因子和其他免疫因子，提供抑菌、杀菌、抗病毒、抗炎和免疫调节保护，防止感染。OMC可能对出生头几天的极低出生体重（ELBW）婴儿特别有保护作用；然而，临床不稳定通常排除在此期间肠内喂养。口咽部给药是一种潜在的替代方法。口咽给药OMC可能对接受者婴儿具有免疫调节作用，尤其对ELBW婴儿有益，否则在出生最初几天将保持零免疫。
Studies in adults have shown that the oropharyngeal route can be used to effectively and safely administer interferon-α, an immune cell-derived cytokine, to patients who are unable to tolerate its parenteral administration. The mechanism for this appears to be the stimulatory effects of the cytokine, on the oropharyngeal-associated lymphoid tissue system. Own mother’s colostrum (OMC) is rich in cytokines and other immune agents that provide bacteriostatic, bacteriocidal, antiviral, anti-inflammatory and immunomodulatory protection against infection. OMC may be especially protective for the extremely low birth weight (ELBW) infant in the first days of life; however clinical instability typically precludes enteral feedings during this period. Oropharyngeal administration is a potential alternative method of providing OMC. Oropharyngeal administration of OMC may have immunomodulatory effects on the recipient infant, and would be especially beneficial to the ELBW infant who would otherwise remain nil per os during the first days of life.
登录
查看更多内容
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
4.5
作者：
BOCCI, V
通讯作者：
BOCCI, V
DOI：
10.1007/978-0-387-74087-4_16
发表时间：
2008-01-01
期刊：
BIOACTIVE COMPONENTS OF MILK
影响因子：
--
作者：
Blum, Juerg. W.;Baumrucker, Craig R.
通讯作者：
Baumrucker, Craig R.
影响因子：
3.6
作者：
Dvorak, B;Fituch, CC;Schanler, RJ
通讯作者：
Schanler, RJ
影响因子：
3.6
作者：
Caplan, MS;Lickerman, M;Yu, A
通讯作者：
Yu, A