Genome SEGE: a database for 'intronless' genes in eukaryotic genomes.
Genome SEGE: a database for 'intronless' genes in eukaryotic genomes.
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DOI：
10.1186/1471-2105-5-67
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发表时间：
2004-06-02
影响因子：
3
通讯作者：
Kangueane P
中科院分区：
文献类型：
--
作者：
Sakharkar MK;Kangueane P
许多完全测序的真核生物基因组数据在公共领域是可用的。真核基因是“含内含子”或“无内含子”的。真核无内含子基因是比较基因组学和进化研究的重要数据集。SEGE数据库包含真核生物单外显子基因的集合。然而，SEGE是使用GenBank获得的。GenBank数据的冗余、不完整和异质性是比较基因组学和进化研究中生物学研究的瓶颈。这些研究通常需要来自每个基因组的代表性基因集，这只有通过从完全测序的基因组数据中导出特定数据集才有可能。因此，基因组SEGE，一个数据库的'内含子'基因在完全测序的真核生物基因组，已经建成。可用性：真核“无内含子”基因是从9个完全测序的基因组中提取的（其中4个是单细胞的，5个是多细胞的）。完整的数据集可供下载。数据子集也可用于“无内含子”假基因。该数据库提供了关于“无内含子”基因在不同基因组中的分布及其在每个基因组中的长度分布的信息。此外，搜索工具提供了数据库中每个序列的预先计算的PROSITE基序，并提供了到InterPro的适当超链接。还可通过网络服务器使用搜索设施。区别Genome SEGE和SEGE的独特功能是为完全测序的基因组提供代表性的“无内含子”数据集。该数据库中的“无内含子”基因集将用于比较基因组学和进化研究中的后续生物计算分析。这种分析可能有助于重新审视原始基因组数据，以进行重新检查和重新注释。
A number of completely sequenced eukaryotic genome data are available in the public domain. Eukaryotic genes are either 'intron containing' or 'intronless'. Eukaryotic 'intronless' genes are interesting datasets for comparative genomics and evolutionary studies. The SEGE database containing a collection of eukaryotic single exon genes is available. However, SEGE is derived using GenBank. The redundant, incomplete and heterogeneous qualities of GenBank data are a bottleneck for biological investigation in comparative genomics and evolutionary studies. Such studies often require representative gene sets from each genome and this is possible only by deriving specific datasets from completely sequenced genome data. Thus Genome SEGE, a database for 'intronless' genes in completely sequenced eukaryotic genomes, has been constructed. Availability: Eukaryotic 'intronless' genes are extracted from nine completely sequenced genomes (four of which are unicellular and five of which are multi-cellular). The complete dataset is available for download. Data subsets are also available for 'intronless' pseudo-genes. The database provides information on the distribution of 'intronless' genes in different genomes together with their length distributions in each genome. Additionally, the search tool provides pre-computed PROSITE motifs for each sequence in the database with appropriate hyperlinks to InterPro. A search facility is also available through the web server. The unique features that distinguish Genome SEGE from SEGE is the service providing representative 'intronless' datasets for completely sequenced genomes. 'Intronless' gene sets available in this database will be of use for subsequent bio-computational analysis in comparative genomics and evolutionary studies. Such analysis may help to revisit the original genome data for re-examination and re-annotation.
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影响因子：
14.9
作者：
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通讯作者：
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