Viral Hypothesis and Antiviral Treatment in Alzheimer's Disease.
Viral Hypothesis and Antiviral Treatment in Alzheimer's Disease.
复制标题
DOI：
10.1007/s11910-018-0863-1
复制
发表时间：
2018-07-14
影响因子：
5.6
通讯作者：
Devanand DP
中科院分区：
文献类型：
--
作者：
Devanand DP
Viruses, particularly herpes simplex virus (HSV), may be a cause of Alzheimer’s disease (AD). The evidence supporting the viral hypothesis suggests that antiviral treatment trials, which have not been conducted, are warranted. HSV1 (oral herpes) and HSV2 (genital herpes) can trigger amyloid aggregation, and their DNA is common in amyloid plaques. HSV1 reactivation is associated with tau hyperphosphorylation and possibly tau propagation. Anti-HSV drugs reduce Aβ and p-tau accumulation in infected mouse brains. Clinically, after the initial oral infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and recurrent reactivation may produce neuronal damage and AD pathology. Clinical studies show cognitive impairment in HSV seropositive patients, and antiviral drugs show strong efficacy against HSV. An antiviral treatment trial in AD is clearly warranted. A phase II treatment trial with valacyclovir, an anti-HSV drug, recently began with evaluation of clinical and biomarker outcomes.
登录
查看更多内容
阿尔茨海默病的脑内传播：加强单纯疱疹病毒病因学的证据。
DOI：
10.1016/j.jalz.2012.07.005
发表时间：
2013-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Ball MJ;Lukiw WJ;Kammerman EM;Hill JM
通讯作者：
Hill JM
影响因子：
5.4
作者：
Burgos, JS;Ramirez, C;Valdivieso, F
通讯作者：
Valdivieso, F
影响因子：
3.3
作者：
Carter, Chris J.
通讯作者：
Carter, Chris J.
影响因子：
4.5
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
通讯作者：
Yolken, Robert
影响因子：
5.9
作者：
Gillet, Laurent;Frederico, Bruno;Stevenson, Philip G.
通讯作者：
Stevenson, Philip G.