Salivary microbiome with gastroesophageal reflux disease and treatment.
Salivary microbiome with gastroesophageal reflux disease and treatment.
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DOI：
10.1038/s41598-020-80170-y
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发表时间：
2021-01-08
影响因子：
4.6
通讯作者：
Adami GR
中科院分区：
文献类型：
--
作者：
Kawar N;Park SG;Schwartz JL;Callahan N;Obrez A;Yang B;Chen Z;Adami GR
口腔微生物组成对牙周健康和全身健康的影响已经并正在确立。反过来，口腔微生物群可能会因局部和全身疾病和状况而改变。胃食道反流病(GERD)与口腔内酸度增加导致牙齿侵蚀有关，并且有争议地降低了患牙周病的风险。我们假设GERD的存在与未经治疗的GERD患者的微生物谱改变有关，并且在GERD患者中使用质子泵抑制剂(PPI)药物：肠道微生物组的有效破坏者，可能会导致唾液微生物组进一步截然不同。与健康对照组相比，未经治疗的GERD患者在唾液微生物群上表现出多种差异。与未经PPI处理的GERD有关的较低水平的分类群包括：黑素普雷沃特氏菌、苍白普雷沃特氏菌、细毛杆菌和莫雷氏Solbacteria等13种。相比之下，长期使用PPI的GERD患者与不使用PPI的健康对照组相比，唾液分类显示出微小的差异。
The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased acidity in the oral cavity resulting in dental erosion, and controversially a reduced risk of periodontal disease. We hypothesized that presence of GERD was linked to a modified microbial profile in untreated GERD patients and that the use of proton pump inhibitor (PPI) drugs: potent disruptors of gut microbiome, in GERD patients might result in a salivary microbiome that is further distinct. Untreated GERD patients showed multiple differences in salivary microbiome as compared to healthy controls. Taxa found at lower levels related to the presence of GERD not treated by PPI included: Prevotella melaninogenica, Prevotella pallens, Leptotrichia, and Solobacterium moorei and thirteen others. In contrast, GERD patients chronically using PPI showed minimal differences in salivary taxa compared to healthy controls not using PPI.
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影响因子：
4.4
作者：
Mejia A;Kraft WK
通讯作者：
Kraft WK
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
6.7
作者：
Darby, IB;Hedge, PJ;Kinane, DF
通讯作者：
Kinane, DF
影响因子：
29.4
作者：
Moayyedi, Paul;Eikelboom, John W.;Yusuf, Salim
通讯作者：
Yusuf, Salim
影响因子：
3.8
作者：
Gazdeck, R. Kyle;Fruscione, Sarah R.;Schwartz, Joel L.
通讯作者：
Schwartz, Joel L.