Medial prefrontal cortex damage affects physiological and psychological stress responses differently in men and women.
Medial prefrontal cortex damage affects physiological and psychological stress responses differently in men and women.
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DOI：
10.1016/j.psyneuen.2009.09.006
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发表时间：
2010-01
影响因子：
3.7
通讯作者：
Tranel, Daniel
中科院分区：
文献类型：
--
作者：
Buchanan, Tony W.;Driscoll, David;Mowrer, Samantha M.;Sollers, John J., III;Thayer, Julian F.;Kirschbaum, Clemens;Tranel, Daniel
对压力情境产生适当的生理和心理反应的能力取决于对这种情境的准确识别和评估。这种能力对于适当的情绪调节也很重要。许多研究表明，内侧前额叶皮层（mPFC）在情绪调节中起着重要的作用，以及在控制情绪调节的生理终点，如下丘脑-垂体-肾上腺（HPA）轴和自主神经系统（ANS）。此外，最近的研究表明，男性和女性可能在这些情绪调节的神经控制机制方面存在差异。在这里，我们研究了人类mPFC在自我报告，ANS和HPA应激反应中的作用，通过测试一组该区域受损的参与者（9名女性和9名男性），脑损伤的对照组（6名女性和6名男性）和健康的对照参与者（27名女性和27名男性）进行直立挑战和特里尔社会压力测试（TSST）。mPFC参与者在TSST中表现出自我报告的压力增加。在女性中，mPFC损伤导致皮质醇对TSST的反应增加。相比之下，在男性中，mPFC损伤量较大与皮质醇反应降低相关。最后，mPFC损伤的男性在立位挑战期间表现出心脏的自主控制改变（心率升高和高频心率变异性降低）。这些发现支持了这样一种观点，即mPFC参与了对压力的生理和心理反应的调节，并且这种调节可能在男性和女性之间存在差异。
The ability to produce appropriate physiological and psychological responses to stressful situations depends on accurate recognition and appraisal of such situations. Such ability is also important for proper emotion regulation. A number of studies have suggested that the medial prefrontal cortex (mPFC) plays a significant role in emotion regulation, as well as in the control of physiological endpoints of emotion regulation such as the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS). Further, recent work has suggested that men and women may differ in these mechanisms of neural control of emotion regulation. Here, we examined the role of the human mPFC in self-report, ANS, and HPA stress reactivity by testing a group of participants with damage to this region (9 women and 9 men), a brain damaged comparison group (6 women and 6 men), and healthy comparison participants (27 women and 27 men) on an orthostatic challenge and the Trier Social Stress Test (TSST). The mPFC participants showed heightened self-reported stress in response to the TSST. In women, mPFC damage led to an increased cortisol response to the TSST. By contrast, in men, greater volume of mPFC damage was correlated with a decreased cortisol response. Finally, men with mPFC damage showed altered autonomic control of the heart (higher heart rate and lower high frequency heart rate variability) during an orthostatic challenge. These findings support the idea that the mPFC is involved in the regulation of physiological and psychological responses to stress and that this regulation may differ between men and women.
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影响因子：
5.2
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通讯作者：
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作者：
Buchanan TW;Tranel D;Kirschbaum C
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