Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress.
Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress.
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DOI：
10.1196/annals.1410.012
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Herman JP
中科院分区：
文献类型：
--
作者：
Jankord R;Herman JP
下丘脑-垂体-肾上腺皮质（HPA）轴负责启动所有脊椎动物的糖皮质激素应激反应。该轴的激活受下丘脑室旁核（PVN）的不同传入输入的调节。这篇综述讨论了大脑机制subserving产生和抑制应激反应，重点是边缘系统的贡献，并突出了最近的概念进展组织的应激反应途径在大脑中。首先，HPA轴对心因性刺激的反应是由复杂的神经回路控制的，该神经回路涉及边缘前脑结构和PVN之间的寡突触网络。第二，个别的应力调节结构可以有一个异质性的影响HPA轴的反应，基于解剖微观组织和/或刺激特性。最后，HPA轴过度活跃，根据慢性压力涉及大量的功能，也许是解剖重组的中央压力整合电路。总的来说，这些数据表明，个别大脑区域不只是作为单一的激活剂或抑制剂的HPA轴和网络的方法需要采取充分了解神经内分泌应激反应的性质。
The hypothalamo-pituitary-adrenocortical (HPA) axis is responsible for initiation of glucocorticoid stress responses in all vertebrate animals. Activation of the axis is regulated by diverse afferent input to the hypothalamic paraventricular nucleus (PVN). This review discusses brain mechanisms subserving generation and inhibition of stress responses focusing on the contribution of the limbic system and highlighting recent conceptual advances regarding organization of stress response pathways in the brain. First, control of HPA axis responses to psychogenic stimuli is exerted by a complex neurocircuitry that involves oligosynaptic networks between limbic forebrain structures and the PVN. Second, individual stress-modulatory structures can have a heterogeneous impact on HPA axis responses, based on anatomical microorganization and/or stimulus properties. Finally, HPA axis hyperactivity pursuant to chronic stress involves a substantial functional and perhaps anatomical reorganization of central stress-integrative circuits. Overall, the data suggest that individual brain regions do not merely function as monolithic activators or inhibitors of the HPA axis and that network approaches need be taken to fully understand the nature of the neuroendocrine stress response.
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影响因子：
4.1
作者：
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通讯作者：
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作者：
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作者：
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