Semi-natural housing rescues social behavior and reduces repetitive exploratory behavior of BTBR autistic-like mice.
Semi-natural housing rescues social behavior and reduces repetitive exploratory behavior of BTBR autistic-like mice.
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DOI：
10.1038/s41598-023-43558-0
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发表时间：
2023-09-27
影响因子：
4.6
通讯作者：
Bordey, Angelique
中科院分区：
文献类型：
--
作者：
Binder, Matthew S.;Bordey, Angelique
在小鼠模型中实施环境富集可以带来许多好处，并且可以减少疾病模型（如自闭症谱系障碍（ASD））的行为症状。然而，以前的工作并没有研究早期生活环境丰富对ASD每个核心特征的影响。因此，我们在出生时实施了社交和身体富集，模拟了半自然的住房，并使用BTBR（自闭症样）和C57BL/6 J （B6，野生型）小鼠，将它们与标准住房条件进行比较，研究了其对交流、社交、感官和重复行为的影响。我们发现，环境丰富减轻了幼年BTBR小鼠的社会缺陷，减少了它们的重复探索行为，但不影响它们对粗糙和光滑质地的偏好，也不影响母鼠隔离诱导的幼鼠叫声的数量。环境富集仅影响B6小鼠的叫声特征。对这些数据的一种解释是，生命早期环境富集对治疗ASD的选择性核心特征具有显著的治疗潜力。另一种解释是，减少环境复杂性会导致自闭症易感小鼠的选择性行为缺陷，这表明目前的标准住房可能不是最理想的。总的来说，我们的数据说明了环境对行为的影响程度，并强调了在设计实验和解释行为结果时考虑住房条件的重要性。
Environmental enrichment confers numerous benefits when implemented in murine models and can reduce behavioral symptomatology in models of disease, such as autism spectrum disorder (ASD). However, previous work did not examine the impact of early-life environmental enrichment on each core feature of ASD. We thus implemented a social and physical enrichment at birth, modeling a semi-natural housing, and examined its impact on communicative, social, sensory, and repetitive behaviors using BTBR (autistic-like) and C57BL/6 J (B6, wildtype) mice, comparing them to standard housing conditions. We found that environmental enrichment alleviated the social deficit of juvenile BTBR mice and reduced their repetitive exploratory behavior but did not affect their rough versus smooth texture preference nor the number of maternal isolation-induced pup calls. Environmental enrichment only affected the call characteristics of B6 mice. One interpretation of these data is that early-life environmental enrichment has significant therapeutic potential to treat selective core features of ASD. Another interpretation is that reducing environmental complexity causes selective behavioral deficits in ASD-prone mice suggesting that current standard housing may be suboptimal. Overall, our data illustrate the extent to which the environment influences behavior and highlights the importance of considering housing conditions when designing experiments and interpreting behavioral results.
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作者：
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