Effects of environmental enrichment on repetitive behaviors in the BTBR T+tf/J mouse model of autism.
Effects of environmental enrichment on repetitive behaviors in the BTBR T+tf/J mouse model of autism.
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DOI：
10.1002/aur.1298
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发表时间：
2013-10
期刊：
影响因子：
4.7
通讯作者：
Devine, Darragh P.
中科院分区：
文献类型：
--
作者：
Reynolds, Stacey;Urruela, Meagan;Devine, Darragh P.
表达自闭症相关行为特征的动物模型已被用于促进我们对可能影响该障碍特定行为方面的因素的理解。BTBR T+tf/J（BTBR）小鼠被描述为自闭症的小鼠模型，因为它显示了自闭症的三个核心特征，包括重复的行为模式。本研究的目的是研究环境富集对BTBR小鼠模型重复行为的数量和质量的影响。两种类型的重复行为进行了检查：1）重复梳理行为作为一个低阶重复运动行为进行了研究，2）重复对象探索作为一个高阶重复认知行为进行了测量。从7周龄的小鼠获得的基线评分证实，BTBR小鼠比对照C57 BL/6 J小鼠花费显著更多的时间理毛，并且使用更严格的理毛顺序。在富集圈养30天后，与置于标准圈养的BTBR小鼠相比，BTBR小鼠表现出梳理毛发所花费的时间显著减少;在富集和标准圈养的BTBR小鼠之间的梳理顺序方面未发现差异。在基线时，在BTBR小鼠和对照小鼠之间没有发现物体探索任务的差异。此外，在富集笼与标准笼中饲养的BTBR小鼠之间，未发现与连续物体探索相关的差异。结果表明，丰富的环境可能有利于减少从事低阶重复行为的时间，但可能不会改变行为的整体质量。在BTBR T+tf/J（BTBR）小鼠品系中已经记录了低阶和高阶重复行为，这是一种表现出定义自闭症的所有三个核心行为领域的小鼠模型。本研究的目的是评估环境富集对减少BTBR小鼠重复行为的有效性。低阶的行为被捕获的时间和序列的梳理，而高阶的行为进行了测量，使用模式分析的对象探索任务从数字记录。在7周龄时建立基线评分，随后在标准或富集笼中饲养30天。正如预期的那样，BTBR小鼠在基线时比对照C57 BL/6 J小鼠花费了显著更多的时间梳理毛发，并且具有更严格的梳理顺序。在30天的富集圈养后，BTBR小鼠表现出梳理毛发所花费的时间显著减少，导致水平低于标准圈养中BTBR小鼠所表现出的水平。然而，没有变化，注意到他们的梳理序列的刚性。与先前的发现相反，在物体探索测试中，BTBR和C57 BL/6 J小鼠之间在基线处的重复探索模式没有差异。随后，丰富并没有显着改变重复模式的数量在后测。总体而言，结果表明，环境丰富可能有利于减少从事低阶重复行为的时间，但可能不会改变行为的整体质量。
Animal models that express autism-related behavioral characteristics have been used to promote our understanding of factors that can influence specific behavioral aspects of the disorder. The BTBR T+tf/J (BTBR) mouse has been described as a mouse model of autism because it displays three core features of the disorder, including repetitive behavior patterns. The purpose of this study was to examine the effects of environmental enrichment on the quantity and quality of repetitive behaviors in the BTBR mouse model. Two types of repetitive behavior were examined: 1) repetitive grooming behaviors were investigated as a lower-order repetitive motor behavior and 2) repetitive object exploration was measured as a higher-order repetitive cognitive behavior. Baseline scores taken from mice at seven weeks of age confirmed that BTBR mice spend significantly more time grooming than control C57BL/6J mice and use a more rigid grooming sequence. After thirty days of enrichment housing, BTBR mice demonstrated a significant reduction in time spent grooming compared to BTBR mice placed in standard housing; no differences were found with regard to grooming sequence between enriched and standard housed BTBR mice. At baseline no differences were found between BTBR mice and control mice for the object exploration task. In addition, no differences were found in relation to sequential object exploration between BTBR mice housed in enriched vs. standard cages. The results suggest that environmental enrichment may be beneficial for reducing time spent engaging in lower-order repetitive behaviors, but may not change the overall quality of the behaviors when they do manifest. Lower order and higher order repetitive behaviors have been documented in the BTBR T+tf/J (BTBR) mouse strain, a mouse model that exhibits all three core behavioral domains that define autism. The purpose of this study was to evaluate the effectiveness of environmental enrichment for reducing repetitive behaviors in BTBR mice. Lower order behaviors were captured by assaying the time and sequence of grooming, while higher order behaviors were measured using pattern analysis of an object exploration task from digital recordings. Baseline scores were established at seven weeks of age followed by 30 days of housing in either a standard or enriched cage. As expected, BTBR mice spent significantly more time grooming and had a more rigid grooming sequence than control C57BL/6J mice did at baseline. After 30 days of enrichment housing, BTBR mice demonstrated a significant reduction in time spent grooming, resulting in levels that were lower than those exhibited by BTBR mice in standard housing. However, no changes were noted in the rigidity of their grooming sequence. In contrast to previous findings, there was no difference in repetitive patterns of exploration at baseline between BTBR and C57BL/6J mice on the object exploration test. Subsequently, enrichment did not significantly alter the number of repetitive patterns at posttest. Overall the results suggest that environmental enrichment may be beneficial for reducing the time spent engaging in lower-order repetitive behaviors, but may not change the overall quality of the behaviors when they do manifest.
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影响因子：
2.7
作者：
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通讯作者：
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DOI：
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