Epigenetic control of gene regulation during development and disease: A view from the retina.
Epigenetic control of gene regulation during development and disease: A view from the retina.
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DOI：
10.1016/j.preteyeres.2018.03.002
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发表时间：
2018-07
影响因子：
17.8
通讯作者：
Swaroop A
中科院分区：
文献类型：
--
作者：
Corso-Díaz X;Jaeger C;Chaitankar V;Swaroop A
复杂的生物过程，如器官发生和体内平衡，是由遗传程序严格调节的，这些遗传程序由表观遗传因素微调，以建立细胞命运和/或对微环境作出反应。指导细胞分化和功能的基因调控网络是通过DNA、RNA和蛋白质的修饰来调节和稳定的。在这篇综述中，我们关注两个关键的表观遗传变化- DNA甲基化和组蛋白修饰-并讨论它们对视网膜发育，衰老和疾病的贡献，特别是在年龄相关性黄斑变性（AMD）和糖尿病视网膜病变的背景下。我们强调了较少研究的DNA甲基化作用，并提供了与其他组织相比，人类和小鼠视网膜中表观遗传酶的RNA表达谱。我们还回顾了计算工具和新兴技术来描述，分析和整合表观遗传信息。我们建议使用编辑工具和单细胞技术来追踪和干扰表观基因组，以描述其在转录调控中的作用。最后，我们提出了在视网膜代谢、疾病建模和再生中探索表观基因组的令人兴奋的途径。
Complex biological processes, such as organogenesis and homeostasis, are stringently regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates and/or to respond to the microenvironment. Gene regulatory networks that guide cell differentiation and function are modulated and stabilized by modifications to DNA, RNA and proteins. In this review, we focus on two key epigenetic changes – DNA methylation and histone modifications – and discuss their contribution to retinal development, aging and disease, especially in the context of age-related macular degeneration (AMD) and diabetic retinopathy. We highlight less-studied roles of DNA methylation and provide the RNA expression profiles of epigenetic enzymes in human and mouse retina in comparison to other tissues. We also review computational tools and emergent technologies to profile, analyze and integrate epigenetic information. We suggest implementation of editing tools and single-cell technologies to trace and perturb the epigenome for delineating its role in transcriptional regulation. Finally, we present our thoughts on exciting avenues for exploring epigenome in retinal metabolism, disease modeling, and regeneration.
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影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
通讯作者：
Church, George M.
在发育，重编程和肿瘤发生过程中，视网膜的动态表观遗传景观。
影响因子：
16.2
作者：
Aldiri I;Xu B;Wang L;Chen X;Hiler D;Griffiths L;Valentine M;Shirinifard A;Thiagarajan S;Sablauer A;Barabas ME;Zhang J;Johnson D;Frase S;Zhou X;Easton J;Zhang J;Mardis ER;Wilson RK;Downing JR;Dyer MA;St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project
通讯作者：
St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project
在单细胞水平上表观遗传调节的动力学。
DOI：
10.1126/science.aab2956
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bintu L;Yong J;Antebi YE;McCue K;Kazuki Y;Uno N;Oshimura M;Elowitz MB
通讯作者：
Elowitz MB
影响因子：
3.7
作者：
Anderson K;Taylor DA;Thompson EL;Melwani AR;Nair SV;Raftos DA
通讯作者：
Raftos DA
影响因子：
4.4
作者：
Bhattacharya, Sujoy;Chaum, Edward;Johnson, Leonard R.
通讯作者：
Johnson, Leonard R.