Marijuana use and DNA methylation-based biological age in young adults.
Marijuana use and DNA methylation-based biological age in young adults.
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DOI：
10.1186/s13148-022-01359-8
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发表时间：
2022-10-26
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
大麻是美国第三大最常用的药物，将其合法化用于医疗和娱乐用途的努力正在增加。尽管使用量增加，大麻对衰老的影响仍然没有得到充分研究，了解大麻对分子衰老的影响可能会为大麻在衰老过程中的作用提供新的见解。因此，我们试图调查累积和最近使用大麻与血液DNA甲基化估计的表观遗传年龄加速（EAA）之间的关联。来自年轻人冠状动脉风险发展（CARDIA）研究的参与者的随机子集在检查年（Y）15和Y 20时具有可用的全血，进行表观基因组分析。根据在Y15和Y20测量的DNA甲基化水平计算四种EAA估计值（内在表观遗传年龄加速、外在表观遗传年龄加速、PhenoAge加速和GrimAge加速）。从基线访视到Y15和Y20计算了曾经使用和累积大麻年数，并在Y15和Y20计算了最近的大麻使用（过去30天内的任何使用天数）。使用广义估计方程，曾经使用大麻和每增加一年大麻分别与6个月（P < 0.001）和2.5个月（P < 0.001）的平均GrimAge加速度（GAA）相关。最近使用和最近使用的每增加一天分别与20个月（P < 0.001）和1个月（P < 0.001）的GAA增加相关。大麻年和饮酒量对GAA的统计学相互作用被观察到（P = 0.011），不饮酒者表现出更高的GAA（β = 0.21 [95% CI 0.05，0.36]，P = 0.008）与重度饮酒者（β = 0.05 [95% CI-0.09，0.18]，P = 0.500）相比，每增加一个大麻年。其余EAA估计值未观察到相关性。这些发现表明，累积和最近的大麻使用与年龄相关的表观遗传变化有关，这些变化与寿命有关。这些观察到的关联可能会被酒精消费所改变。鉴于大麻使用和合法化的增加，这些发现为大麻使用对衰老过程的影响提供了新的见解，这些影响通过血液DNA甲基化来捕获。在线版本包含补充材料，可通过10.1186/s13148-022-01359-8获得。
Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied and understanding the effects of marijuana on molecular aging may provide novel insights into the role of marijuana in the aging process. We therefore sought to investigate the association between cumulative and recent use of marijuana with epigenetic age acceleration (EAA) as estimated from blood DNA methylation. A random subset of participants from The Coronary Artery Risk Development in Young Adults (CARDIA) Study with available whole blood at examination years (Y) 15 and Y20 underwent epigenomic profiling. Four EAA estimates (intrinsic epigenetic age acceleration, extrinsic epigenetic age acceleration, PhenoAge acceleration, and GrimAge acceleration) were calculated from DNA methylation levels measured at Y15 and Y20. Ever use and cumulative marijuana-years were calculated from the baseline visit to Y15 and Y20, and recent marijuana use (both any and number of days of use in the last 30 days) were calculated at Y15 and Y20. Ever use of marijuana and each additional marijuana-year were associated with a 6-month (P < 0.001) and a 2.5-month (P < 0.001) higher average in GrimAge acceleration (GAA) using generalized estimating equations, respectively. Recent use and each additional day of recent use were associated with a 20-month (P < 0.001) and a 1-month (P < 0.001) higher GAA, respectively. A statistical interaction between marijuana-years and alcohol consumption on GAA was observed (P = 0.011), with nondrinkers exhibiting a higher GAA (β = 0.21 [95% CI 0.05, 0.36], P = 0.008) compared to heavy drinkers (β = 0.05 [95% CI − 0.09, 0.18], P = 0.500) per each additional marijuana-year. No associations were observed for the remaining EAA estimates. These findings suggest cumulative and recent marijuana use are associated with age-related epigenetic changes that are related to lifespan. These observed associations may be modified by alcohol consumption. Given the increase in use and legalization, these findings provide novel insight on the effect of marijuana use on the aging process as captured through blood DNA methylation. The online version contains supplementary material available at 10.1186/s13148-022-01359-8.
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影响因子：
3.7
作者：
Juknat A;Pietr M;Kozela E;Rimmerman N;Levy R;Gao F;Coppola G;Geschwind D;Vogel Z
通讯作者：
Vogel Z
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.1503/cmaj.202392
发表时间：
2021-09-07
期刊：
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
影响因子：
--
作者：
Ladha KS;Mistry N;Wijeysundera DN;Clarke H;Verma S;Hare GMT;Mazer CD
通讯作者：
Mazer CD
影响因子：
5.7
作者：
Nannini, Drew R.;Joyce, Brian T.;Hou, Lifang
通讯作者：
Hou, Lifang
影响因子：
3.1
作者：
Bramness, Jorgen G.;von Soest, Tilmann
通讯作者：
von Soest, Tilmann