Comparison of quantitative susceptibility mapping methods on evaluating radiation-induced cerebral microbleeds and basal ganglia at 3T and 7T.
Comparison of quantitative susceptibility mapping methods on evaluating radiation-induced cerebral microbleeds and basal ganglia at 3T and 7T.
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作者：
定量易感性制图（QSM）有潜力成为各种疾病的生物标志物，因为它能够从T2*加权MRI的相位信号中测量与铁沉积、髓磷脂和出血相关的组织易感性。尽管QSM有望成为一种定量标记，但它面临着许多挑战，包括依赖于原始相位数据的预处理，相对较弱的组织信号，以及磁偶极子与测量相位之间固有的病态关系。本研究的目的是评估背景场去除和偶极子反演算法对3T和7T微波背景辐射量化的噪声特性、图像均匀性和结构对比度的影响。选取了四种常用的背景相位去除算法和五种偶极子场反演算法，并将其应用于脑微出血（CMB）患者和志愿者，分别采用两种不同场强的扫描方法和多方向扫描计算的地真值QSM参考值。7T MRI提供的QSM图像噪声比3T MRI低。QSIP和VSHARP + iLSQR获得了最高的白质均匀性和静脉对比度，QSIP也提供了最高的CMB对比度。与地面真实COSMOS QSM图像相比，在基底节区观察到偶极子反演算法的敏感性值与COSMOS参考值之间总体上具有良好的相关性，其中VSHARP + iLSQR在所有区域与COSMOS的敏感性值最相似。该研究可为基于兴趣和扫描仪场强的应用选择最合适的QSM加工流水线提供指导。
Quantitative susceptibility mapping (QSM) has the potential of being a biomarker for various diseases because of its ability to measure tissue susceptibility related to iron deposition, myelin, and hemorrhage from the phase signal of a T2*-weighted MRI. Despite its promise as a quantitative marker, QSM is faced with many challenges, including its dependence on preprocessing of the raw phase data, the relatively weak tissue signal, and the inherently ill-posed relationship between the magnetic dipole and measured phase. The goal of this study was to evaluate the effects of background field removal and dipole inversion algorithms on noise characteristics, image uniformity, and structural contrast for CMB quantification at both 3T and 7T. We selected four widely used background phase removal and five dipole field inversion algorithms for QSM and applied them to patients with cerebral microbleeds (CMB) who were scanned at two different field strengths and volunteers with ground truth QSM reference calculated using multiple orientation scans. 7T MRI provided QSM images with lower noise than 3T MRI. QSIP and VSHARP + iLSQR achieved the highest white matter homogeneity and vein contrast, with QSIP also providing the highest CMB contrast. Compared to ground truth COSMOS QSM images, overall good correlations between susceptibility values of dipole inversion algorithms and the COSMOS reference were observed in basal ganglia regions, with VSHARP + iLSQR achieving the most similar susceptibility values to COSMOS across all regions. This study can provide guidance for selecting the most appropriate QSM processing pipeline based on the application of interest and scanner field strength.
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影响因子：
3.3
作者：
Langkammer C;Schweser F;Shmueli K;Kames C;Li X;Guo L;Milovic C;Kim J;Wei H;Bredies K;Buch S;Guo Y;Liu Z;Meineke J;Rauscher A;Marques JP;Bilgic B
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3.7
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.ijrobp.2011.05.046
发表时间：
2012-03-01
影响因子：
7
作者：
Lupo, Janine M.;Chuang, Cynthia F.;Nelson, Sarah J.
通讯作者：
Nelson, Sarah J.