Impact of a vegan diet on the human salivary microbiota.
Impact of a vegan diet on the human salivary microbiota.
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DOI：
10.1038/s41598-018-24207-3
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发表时间：
2018-04-11
影响因子：
4.6
通讯作者：
Pedersen O
中科院分区：
文献类型：
--
作者：
Hansen TH;Kern T;Bak EG;Kashani A;Allin KH;Nielsen T;Hansen T;Pedersen O
关于长期饮食模式对人类唾液微生物区系的组成和功能潜力的影响，人们知之甚少。在本研究中，我们试图通过16S rRNA基因扩增序列分析160名健康纯素食者和杂食者唾液微生物区系的多样性、组成和功能潜力，为正在进行的饮食对口腔微生物群落的影响的阐明做出贡献。我们进一步试图确定唾液中与宿主炎症标志物相关的细菌分类群。我们发现纯素食者和杂食者唾液微生物区系的组成差异存在于门水平以下的所有分类水平，包括上呼吸道共生体(例如亚黄奈瑟氏菌、副流感嗜血杆菌和粘液玫瑰杆菌)和与牙周病相关的物种(例如直肠弯曲杆菌和牙髓卟啉单胞菌)。食物中的中链脂肪酸、鱼氨酸单不饱和脂肪酸和多不饱和脂肪酸以及膳食纤维的摄入量与细菌多样性、群落结构以及几个物种水平的操作分类单位的相对丰度有关。对推测的基因组潜力的分析显示，在素食主义者和杂食者中，几种代谢途径不同地丰富，这表明宏观和微观营养素摄入可能会产生影响。我们还表明，某些口腔细菌与宿主的全身炎症状态有关。
Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional potential of the salivary microbiota in 160 healthy vegans and omnivores using 16S rRNA gene amplicon sequencing. We further sought to identify bacterial taxa in saliva associated with host inflammatory markers. We show that compositional differences in the salivary microbiota of vegans and omnivores is present at all taxonomic levels below phylum level and includes upper respiratory tract commensals (e.g. Neisseria subflava, Haemophilus parainfluenzae, and Rothia mucilaginosa) and species associated with periodontal disease (e.g. Campylobacter rectus and Porphyromonas endodontalis). Dietary intake of medium chain fatty acids, piscine mono- and polyunsaturated fatty acids, and dietary fibre was associated with bacterial diversity, community structure, as well as relative abundance of several species-level operational taxonomic units. Analysis of imputed genomic potential revealed several metabolic pathways differentially abundant in vegans and omnivores indicating possible effects of macro- and micro-nutrient intake. We also show that certain oral bacteria are associated with the systemic inflammatory state of the host.
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DOI：
10.1084/jem.85.1.9
发表时间：
1947-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dubos RJ
通讯作者：
Dubos RJ
影响因子：
4.6
作者：
Arimatsu K;Yamada H;Miyazawa H;Minagawa T;Nakajima M;Ryder MI;Gotoh K;Motooka D;Nakamura S;Iida T;Yamazaki K
通讯作者：
Yamazaki K
影响因子：
2
作者：
Ercan, Esra;Eratalay, Kenan;Akincibay, Hakan
通讯作者：
Akincibay, Hakan
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y