Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion.
Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion.
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DOI：
10.3390/jcm10173944
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发表时间：
2021-08-31
影响因子：
3.9
通讯作者：
Ozawa Y
中科院分区：
文献类型：
--
作者：
Minami S;Uchida A;Nagai N;Shinoda H;Kurihara T;Ban N;Terasaki H;Takagi H;Tsubota K;Sakamoto T;Ozawa Y
目的：探讨与既往手术无关的增殖性玻璃体视网膜病变C级（PVR-C）发生的危险因素。方法：2016年2月至2017年3月期间，接受孔源性视网膜脱离手术的患者在日本视网膜和玻璃体学会组织的日本视网膜脱离登记处进行前瞻性登记。对术前、术后1、3、6个月的眼科检查数据进行分析。结果：我们纳入了2013例患者的2013只眼睛(男性，1326只（65.9%）；3446例登记患者的平均年龄（55.2±15.2岁）。3.6%的患者术前出现PVR-C。倾向评分匹配显示，较短的轴长（AL）是术前PVR-C的危险因素(OR（优势比），0.81；95% CI（置信区间），0.69 ~ 0.96；p = 0.015)，这是手术失败的危险因素（OR, 4.22; 95% CI, 1.12 ~ 15.93; p = 0.034）；对于AL < 25.0 mm的眼睛，相关性尤为显著（p = 0.016），而对于AL≥25.0 mm的眼睛，相关性不显著。结论：手术侵袭前较短的AL与PVR-C的发生有关。我们的研究结果将有助于阐明PVR的基本发病机制，并提醒临床医生在PVR发生前仔细检查AL较短的眼睛以发现视网膜脱离。
Purpose: To investigate the risk factors for the development of proliferative vitreoretinopathy grade C (PVR-C), independent of prior surgical invasion. Methods: Patients who underwent surgery for rhegmatogenous retinal detachment were prospectively registered with the Japan-Retinal Detachment Registry, organized by the Japanese Retina and Vitreous Society, between February 2016 and March 2017. Data obtained from general ophthalmic examinations performed before and at 1, 3, and 6 months after surgery were analyzed. Results: We included 2013 eyes of 2013 patients (men, 1326 (65.9%); mean age, 55.2 ± 15.2 years) from amongst 3446 registered patients. Preoperative PVR-C was observed in 3.6% of patients. Propensity score matching revealed that a shorter axial length (AL) was a risk factor for preoperative PVR-C (OR (Odds Ratio), 0.81; 95% CI (Confidence Interval), 0.69 to 0.96; p = 0.015), which was a risk factor for surgical failure (OR, 4.22; 95% CI, 1.12 to 15.93; p = 0.034); the association was particularly significant for eyes with an AL < 25.0 mm (p = 0.016), while it was insignificant for eyes with an AL ≥ 25.0 mm. Conclusions: A shorter AL was related to the development of PVR-C before surgical invasion. Our results will help elucidate the fundamental pathogenesis of PVR and caution clinicians to meticulously examine eyes with a shorter AL to detect retinal detachment before PVR development.
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发表时间：
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影响因子：
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