Changes in Microvascular Morphology in Subcortical Vascular Dementia: A Study of Vessel Size Magnetic Resonance Imaging.
Changes in Microvascular Morphology in Subcortical Vascular Dementia: A Study of Vessel Size Magnetic Resonance Imaging.
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DOI：
10.3389/fneur.2020.545450
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发表时间：
2020
影响因子：
3.4
通讯作者：
Jahng GH
中科院分区：
文献类型：
--
作者：
Choi HI;Ryu CW;Kim S;Rhee HY;Jahng GH
背景：脑小血管疾病是皮质下血管性痴呆(SVaD)最常见的病因。不幸的是，传统的成像技术并不总是显示与小血管疾病相关的微血管病变。本研究的目的是评估SVaD的微血管结构的变化，并确定通过成像检测到的血管大小的微血管变化如何影响灰质。方法：10例SVaD患者和12例健康对照在注射造影剂前后分别用梯度回波和自旋回波序列进行血管大小成像。计算总血容量分数(BVF)、平均血管密度(Q)、平均血管直径(MVD)和血管大小指数(VSI)四种微血管指数图。比较SVaD患者和对照组各微血管参数的ROI值。微血管参数的体素比较也被用来评估区域差异。评价脑白质微血管参数与灰质总体积(TGV)的关系。结果：在基于ROI的比较中，SVaD组和对照组的MVD和VSI均有显著差异(非配对t检验，p<；0.05)。SVaD组皮质下、脑室周围白质、基底节和丘脑的MVD和VSI显著高于对照组(FDR校正，p<；0.05)。脑白质区VSI与TGV呈显著负相关(r=−0.446.0 5，P<0.0 5)。结论：SVaD患者MVD和VSI的增加反映了脑白质微血管的损害，这些改变可能导致灰质的损害。
Background: Cerebral small vessel disease is the most common cause of subcortical vascular dementia (SVaD). Unfortunately, conventional imaging techniques do not always demonstrate the microvascular pathology that is associated with small vessel disease. The purpose of this study was to evaluate the changes in the microvascular structure of SVaD and to identify how the microvascular changes in vessel size, detected with imaging, affect the gray matter. Methods: Ten SVaD patients and 12 healthy controls underwent vessel size imaging with gradient-echo and spin-echo sequences before and after contrast agent injection. Four microvessel index maps, including total blood volume fraction (BVf), mean vessel density (Q), mean vessel diameter (mVD), and vessel size index (VSI) were calculated. ROI value of each microvessel parameter was compared between SVaD patients and controls. Voxel-wise comparison of microvessel parameters was also performed to assess the regional difference. The relationship between the microvessel parameters in white matter and total gray matter volume (TGV) were assessed. Results: Both mVD and VSI were significantly different between the SVaD and controls in the ROI-based comparisons (unpaired t-test, p < 0.05). mVD and VSI were significantly increased in the SVaD group at the subcortical, periventricular white matter, basal ganglia, and thalami compared with the controls (FDR corrected, p < 0.05). VSI in the white matter areas were significantly negatively correlated with TGV (r = −0.446, p < 0.05). Conclusions: The increase of mVD and VSI in SVaD patients reflects the damage of the microvessels in the white matter, and these changes may lead to the damage of the gray matter.
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影响因子：
25
作者：
Sowell, ER;Peterson, BS;Toga, AW
通讯作者：
Toga, AW
影响因子：
4.4
作者：
Hsu, Yuan-Yu;Yang, Wei-Shan;Liu, Ho-Ling
通讯作者：
Liu, Ho-Ling
影响因子：
5.7
作者：
Barnes, Josephine;Ridgway, Gerard R.;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
11.3
作者：
O'Brien LM;Ziegler DA;Deutsch CK;Frazier JA;Herbert MR;Locascio JJ
通讯作者：
Locascio JJ
白质超强度和灰质体积与认知障碍的老年人的认知相关性。
影响因子：
3.1
作者：
Arvanitakis Z;Fleischman DA;Arfanakis K;Leurgans SE;Barnes LL;Bennett DA
通讯作者：
Bennett DA