Cerebrovascular reactivity measured with arterial spin labeling and blood oxygen level dependent techniques.
Cerebrovascular reactivity measured with arterial spin labeling and blood oxygen level dependent techniques.
复制标题
用动脉自旋标记和血氧水平依赖性技术测量的脑血管反应性。
DOI：
10.1016/j.mri.2015.02.018
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发表时间：
2015-06
影响因子：
2.5
通讯作者：
Kuo, Anderson H.
中科院分区：
文献类型：
--
作者：
Zhou, Yongxia;Rodgers, Zachary B.;Kuo, Anderson H.
关键词：
比较假连续动脉自旋标记（pCASL）和血氧水平依赖（BOLD）fMRI技术定量脑血管反应性（CVR）。招募了16名健康志愿者（年龄：37.8±14.3岁; 6名女性和10名男性;教育程度：17 ± 2.1岁），并在3 T场强下完成5%CO2气体混合物呼吸范例。假定轻度高碳酸血症不影响脑氧代谢率，采集ASL和BOLD图像用于CVR测定。两种CVR定量均推导为脑血流量分数（CBF）或BOLD信号变化与潮气末CO2压力变化的比值。绝对CBF、BOLD和CVR测量值与文献值一致。脑血流CVR灰质为5.11 ± 0.87%/mmHg，脑实质为4.64 ± 0.37%/mmHg。GM和实质的BOLD CVR分别为0.23± 0.04%/mmHg和0.22± 0.04%/mmHg。BOLD和基于CBF的CVR之间最显著的相关性也存在于GM结构中，枕叶皮质的血管反应大于额叶和顶叶（6.8%/mmHg vs 4.5%/mmHg，高50%）。实质BOLD CVR与高碳酸血症时CBF的分数变化显著相关（r=0.61，P=0.01），表明BOLD反应显著受血流驱动。在室内空气中，GM CBF随年龄增长而降低（GM为-5.58 mL/100 g/min/10年; r=-0.51，P=0.05），但在高碳酸血症期间，CBF与年龄无关。观察到pCASL CVR随年龄增加的趋势，GM的比例为0.64%/mmHg/10年。与先前报道的CVR值一致，我们的研究结果表明，BOLD和CBF CVR技术在评价神经元和血管血流动力学过程的基础上是相互补充的。
To compare cerebrovascular reactivity (CVR) quantified with pseudo-continuous arterial spin labeling (pCASL) and blood oxygen level dependent (BOLD) fMRI techniques. Sixteen healthy volunteers (age: 37.8±14.3 years; 6 women and 10 men; education attainment: 17+2.1 years) were recruited and completed a 5% CO2 gas-mixture breathing paradigm at 3T field strength. ASL and BOLD images were acquired for CVR determination assuming that mild hypercapnia does not affect the cerebral metabolic rate of oxygen. Both CVR quantifications were derived as the ratio of the fractional cerebral blood flow (CBF) or BOLD signal change over the change in end-tidal CO2 pressure. The absolute CBF, BOLD and CVR measures were consistent with literature values. CBF derived CVR was 5.11 ± 0.87%/mmHg in gray matter (GM) and 4.64 ± 0.37%/mmHg in parenchyma. BOLD CVR was 0.23±0.04 %/mmHg and 0.22±0.04 %/mmHg for GM and parenchyma respectively. The most significant correlations between BOLD and CBF-based CVRs were also in GM structures, with greater vascular response in occipital cortex than in frontal and parietal lobes (6.8 %/mmHg versus 4.5 %/mmHg, 50% greater). Parenchymal BOLD CVR correlated significantly with the fractional change in CBF in response to hypercapnia (r=0.61, P=0.01), suggesting the BOLD response to be significantly flow driven. GM CBF decreased with age in room air (-5.58 mL/100g/min per decade for GM; r=-0.51, P=0.05), but there was no association of CBF with age during hypercapnia. A trend toward increased pCASL CVR with age was observed, scaling as 0.64 %/mmHg per decade for GM. Consistent with previously reported CVR values, our results suggest that BOLD and CBF CVR techniques are complementary to each other in evaluating neuronal and vascular underpinning of hemodynamic processes.
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