PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma.
PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma.
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PARP-1 Val762Ala 多态性与宫颈癌风险相关
DOI：
10.1371/journal.pone.0037446
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Ye F;Cheng Q;Hu Y;Zhang J;Chen H
PARP-1是一种核酶，在DNA修复，重组，增殖和基因组稳定性中起重要作用。 PARP-1 VAL762宫颈癌的539名女性，有480名CIN的女性和800个基因分型方法。 CI：1.47–3.70），类似在鳞状细胞癌中也发现了结果（OR：2.56，95％CI：1.47–3.70）在HPV阳性人群中，PARP-1 ALA762ALA基因型也与宫颈癌的风险相关联（OR：5.56，95％CI：2.08-14.3）。 。
PARP-1 is a nuclear enzyme that plays an important role in DNA repair, recombination, proliferation and the genome stability. The PARP-1 Val762Ala polymorphism has been associated with increased risk of developing cancers of the prostate, esophagus and lung. The aim of this study was to determine whether the PARP-1 Val762Ala polymorphism is associated with the risk of cervical carcinoma. MA-PCR was used to genotype the PARP-1 Val762Ala polymorphism in 539 women with cervical carcinoma, 480 women with CIN and 800 controls. The genotyping method was confirmed by the DNA sequencing analysis. The PARP-1 Val762Ala polymorphism was not associated with the risk of CIN. However, women carrying the PARP-1 Ala762Ala genotype were significantly susceptible to cervical carcinoma (OR: 2.70, 95% CI: 1.47–3.70), and the similar results were also found in squamous cell carcinoma (OR: 2.56, 95% CI: 1.47–3.70). In HPV positive population, the PARP-1 Ala762Ala genotype was also associated with increased risk of cervical carcinoma (OR: 5.56, 95% CI: 2.08–14.3). Our results indicate that the PARP-1 Ala762Ala genotype increases the risk of cervical carcinoma.
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