Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study.
Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study.
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DOI：
10.1016/j.annepidem.2010.05.002
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发表时间：
2010-12
影响因子：
5.6
通讯作者：
Trevisan, Maurizio
中科院分区：
文献类型：
--
作者：
Rafalson, Lisa;Donahue, Richard P.;Stranges, Saverio;Lamonte, Michael J.;Dmochowski, Jacek;Dorn, Joan;Trevisan, Maurizio
关键词：
在西纽约健康研究的6年随访中，研究睡眠持续时间是否与空腹血糖受损（IFG）事件相关。参与者（n= 1，455，应答率68%）在基线（1996-2001）时无2型糖尿病和已知心血管疾病，并于2003-2004年进行复查。进行了巢式病例对照研究。病例基线时空腹血糖（FPG）< 100 mg/dl，随访时为100 - 125 mg/dl;对照组（n=272）两次检查时FPG <100 mg/dl。病例（n=91）与三个对照组（n=272）在性别、种族和研究入组年份上单独匹配。平均睡眠时间分为短睡眠<6小时，中睡眠6至8小时，长睡眠> 8小时。在多变量条件Logistic回归中，调整了几个糖尿病危险因素后，与中等睡眠者相比，短睡眠者IFG的比值比（OR）为3.0（95%CI 1.05，8.59）。长时间睡眠与IFG之间没有关联：OR 1.6（95% CI：0.45.-0.25）。5.42）。胰岛素抵抗的调整仅削弱了短睡眠者的相关性OR 2.5（95%CI：0.83，7.46）。睡眠时间短与IFG风险升高相关。胰岛素抵抗似乎介导了这种关联。
To examine whether sleep duration was associated with incident impaired fasting glucose (IFG) over six years of follow-up in the Western New York Health Study. Participants (n= 1,455, 68% response rate) who were free of type 2 diabetes and known cardiovascular disease at baseline (1996-2001) were reexamined in 2003-2004. A nested case-control study was conducted. Cases had fasting plasma glucose (FPG) < 100 mg/dl at baseline and 100 to 125 mg/dl at follow-up: controls (n=272) had FPG <100 mg/dl at both exams. Cases (n=91) were individually matched to three controls (n=272) on sex, race, and year of study enrollment. Average sleep duration was categorized as short < 6h, mid-range 6 to 8h, and long-sleep > 8h. In multivariate conditional logistic regression after adjustment for several diabetes risk factors the Odds Ratio (OR) of IFG among short sleepers was 3.0 (95% CI 1.05, 8.59) compared to mid-range sleepers. There was no association between long sleep and IFG: OR 1.6 (95% CI: 0.45.-5.42). Adjustment for insulin resistance attenuated the association only among short sleepers OR 2.5 (95% CI: 0.83, 7.46). Short sleep duration was associated with an elevated risk of IFG. Insulin resistance appears to mediate this association.
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影响因子：
5
作者：
Stranges, Saverio;Dorn, Joan M.;Cappuccio, Francesco P.
通讯作者：
Cappuccio, Francesco P.
DOI：
10.1097/med.0b013e3282be9093
发表时间：
2007-10-01
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Penev, Plamen D
通讯作者：
Penev, Plamen D
影响因子：
6
作者：
Trevisan, M;Dorn, J;Hovey, K
通讯作者：
Hovey, K
影响因子：
16.2
作者：
Ayas, NT;White, DP;Hu, FB
通讯作者：
Hu, FB
影响因子：
4.2
作者：
Dorn, JM;Hovey, K;Trevisan, M
通讯作者：
Trevisan, M