Ambulatory function in motor incomplete spinal cord injury: a magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry.
Ambulatory function in motor incomplete spinal cord injury: a magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry.
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DOI：
10.1038/sc.2017.18
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发表时间：
2017-07
期刊：
影响因子：
2.2
通讯作者：
Elliott JM
中科院分区：
文献类型：
--
作者：
Smith AC;Weber KA;Parrish TB;Hornby TG;Tysseling VM;McPherson JG;Wasielewski M;Elliott JM
本研究采用横断面设计。脊髓水肿长度已被测量与T2加权矢状MRI预测运动恢复脊髓损伤后。本研究的目的是建立轴性脊髓水肿的相关值使用T2加权MRI。我们假设轴向MRI上的损伤大小与运动不完全性脊髓损伤（iSCI）中观察到的行走能力、运动功能和远端肌肉变化之间存在直接关系。位于美国伊利诺伊州芝加哥的大学实验室。14名iSCI患者参加了这项研究。采用轴向T2加权MRI评估脊髓轴向损伤率。采用6分钟步行试验和每日步幅计数研究步行能力。最大跖屈扭矩采用等长测力法进行定量。使用脂肪/水分离磁共振成像定量肌肉脂肪浸润（MFI）和相对肌肉横截面积（rmCSA）。损伤率与6分钟步行距离、平均每日步幅和最大跖屈扭矩呈负相关，损伤率与小腿rmCSA呈负线性趋势。虽然损伤率与MFI没有显着相关性，但我们发现轮椅使用者参与组的MFI显着高于社区步行者。损伤率可能对脊髓损伤后运动功能恢复的预后有帮助。研究结果证明了一项大型多中心研究，以探讨高分辨率轴向T2加权成像预测运动不完全性脊髓损伤后步行恢复的价值。
This research utilized a cross-sectional design. Spinal cord edema length has been measured with T2-weighted sagittal MRI to predict motor recovery following spinal cord injury. The purpose of our study was to establish the correlational value of axial spinal cord edema using T2-weighted MRI. We hypothesized a direct relationship between the size of damage on axial MRI and walking ability, motor function, and distal muscle changes seen in motor incomplete spinal cord injury (iSCI). University based laboratory in Chicago, IL USA. Fourteen participants with iSCI took part in the study. Spinal cord axial damage ratios were assessed using axial T2-weighted MRI. Walking ability was investigated using the 6-minute walk test and daily stride counts. Maximum plantarflexion torque was quantified using isometric dynomometry. Muscle fat infiltration (MFI) and relative muscle cross sectional area (rmCSA) were quantified using fat/water separation magnetic resonance imaging. Damage ratios were negatively correlated with distance walked in 6 minutes, average daily strides, and maximum plantarflexion torque, and a negative linear trend was found between damage ratios and lower leg rmCSA. While damage ratios were not significantly correlated with MFI, we found significantly higher MFI in the wheelchair user participant group compared to community walkers. Damage ratios may be useful in prognosis of motor recovery in spinal cord injury. The results warrant a large multi-site research study to investigate the value of high-resolution axial T2-weighted imaging to predict walking recovery following motor incomplete spinal cord injury.
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影响因子：
5.8
作者：
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