Preparative Enrichment and Separation of Glycyrrhetinic Acid Monoglucuronide from Fermentation Broths with Macroporous Resins
Preparative Enrichment and Separation of Glycyrrhetinic Acid Monoglucuronide from Fermentation Broths with Macroporous Resins
复制标题
大孔树脂从发酵液中制备富集和分离甘草次酸单葡萄糖苷酸
DOI：
10.1080/01496395.2011.637280
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发表时间：
2012-02
影响因子：
2.8
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zou SP;Zhou JJ;Imdad K;Xie LP;Liu GY;Li C
采用6种不同理化性质的大孔吸附树脂对经预处理的大黄素发酵液中大黄次酸单葡萄糖醛酸苷（GAMG）进行富集分离。D101树脂在所测试的树脂中显示出最大的效果。用Langmuir和Freundlich等温线描述了不同温度下D101树脂对溶质的亲和性，平衡实验数据与两条等温线拟合良好。通过动态吸附和脱附实验，优化了高效分离GAMG的操作参数。经D101树脂一次处理后，产品中的GAMG含量提高了8.2倍，回收率为93.3%。该工艺实现了D101大孔吸附树脂对GAMG的富集和分离，可用于从发酵液中大规模制备GAMG。
Preparative enrichment and separation of Glycyrrhetinic acid monoglucuronide (GAMG) from the pretreated fermentation broth of glycyrrhizin was studied by using six macroporous resins with different physical and chemical properties. D101 resin showed the maximum effectiveness among the tested resins. The solute affinity towards D101 resin at different temperatures was described in terms of Langmuir and Freundlich isotherms, and the equilibrium experimental data were well-fitted to the two isotherms. The dynamic adsorption and desorption tests were carried out in order to optimize the operational parameters for the efficient separation of GAMG. After one run treatment with D101 resin, the contents of GAMG in the product were increased to 8.2-fold with recovery yields of 93.3%. The process achieved easy and effective enrichment and separation of GAMG with D101 resin, and it could be applied for the large-scale preparation of GAMG from the fermentation broth of glycyrrhizin.
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影响因子：
4.1
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通讯作者：
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影响因子：
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通讯作者：
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