Height, nevus count, and risk of cutaneous malignant melanoma: Results from 2 large cohorts of US women.
Height, nevus count, and risk of cutaneous malignant melanoma: Results from 2 large cohorts of US women.
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DOI：
10.1016/j.jaad.2020.04.158
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发表时间：
2020-10
影响因子：
13.8
通讯作者：
Nan, Hongmei
中科院分区：
文献类型：
--
作者：
Li, Xin;Kraft, Peter;De Vivo, Immaculata;Giovannucci, Edward;Liang, Liming;Nan, Hongmei
个子高的人患黑色素瘤的风险更高。在护士健康研究(NHS)和NHS2的高加索人参与者中，前瞻性地调查身高与雀斑计数和黑色素瘤的关系，并估计由雀斑计数解释的身高-黑色素瘤相关性的比例。我们使用COX比例风险回归和多项Logistic回归进行数据分析，并调整多变量模型中的潜在混杂因素。我们分别包括82,468名NHS和106,069名来自NHS和NHS2的女性。身高每增加10厘米与黑色素瘤的风险比为1.21[95%可信区间：1.12，1.31]。与没有痣的女性相比，身高增加10厘米的女性在NHS和NHS2中身高增加10厘米的优势比(95%CI)分别为1.35(1.23，1.48)和1.12(1.09，1.15)。NHS和NHS2的黑色素瘤风险分别为8.03%和10.22%，与身高每增加10厘米相关的比例是8.03%。自我报告的身高和雀斑计数。鼹鼠计数仅限于一只胳膊或两条腿。痣的数量是高加索高加索女性患黑色素瘤风险过高的重要解释因素。
Taller individuals are at higher risk of melanoma. To prospectively investigate the association of height with nevus count and melanoma and estimate the proportion of height-melanoma association explained by nevus count among Caucasian participants from the Nurses’ Health Study (NHS) and NHS2. We used Cox proportional hazards regression and multinomial logistic regression for data analyses with adjustment of potential confounders in the multivariate model. We included 82,468 and 106,069 women from the NHS and NHS2, respectively. The hazard ratio was 1.21 [95% confidence interval (CI): 1.12, 1.31] for the association between every 10-cm increase in height and melanoma. Compared to women with no nevi, the odds ratios (95% CIs) associated with 10-cm increase in height were 1.35 (1.23, 1.48) in the NHS and 1.12 (1.09, 1.15) in the NHS2 for women with 10+ moles. The proportion of excess melanoma risk associated with per 10-cm increase in height explained by nevus count was 8.03% in the NHS and 10.22% in the NHS2. Self-reported height and nevus count. Mole counts were limited to one arm or both legs. Nevus count is an important explanatory factor for the excess risk of melanoma among taller Caucasians women.
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影响因子：
4.8
作者：
Clewes, Oliver;Narytnyk, Alla;Gillinder, Kevin R.;Loughney, Andrew D.;Murdoch, Alison P.;Sieber-Blum, Maya
通讯作者：
Sieber-Blum, Maya
影响因子：
51.1
作者：
Green, Jane;Cairns, Benjamin J.;Casabonne, Delphine;Wright, F. Lucy;Reeves, Gillian;Beral, Valerie
通讯作者：
Beral, Valerie
影响因子：
8.8
作者：
Li, Xin;Liang, Liming;Han, Jiali
通讯作者：
Han, Jiali
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
10.3
作者：
ALBANES, D;WINICK, M
通讯作者：
WINICK, M