Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors.
Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors.
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DOI：
10.1167/iovs.64.15.19
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发表时间：
2023-12-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
目的观察急性高眼压下视神经乳头（ONH）深部组织的变形。经研究同意的脑死亡器官捐献者接受了光谱域光学相干断层扫描（OCT）成像。重复OCT成像，同时将眼睛顺序保持在10、30和50 mm Hg的测压压力下。ONH的径向扫描通过深度学习自动分割，并通过自定义算法进行三维量化。筛板（LC）深度和脉络膜厚度的变化与眼压和年龄的线性混合效应模型。LC深度根据常用参考平面计算。对来自20名脑死亡器官捐献者（年龄范围，22-62岁;中位年龄，43岁）的26只眼睛进行成像和定量。根据基于布鲁赫膜（BM）、BM开口和前巩膜管开口平面的参考平面测量的LC深度显示LC深度随着IOP升高而减少和增加。当相对于巩膜参考平面测量时，LC深度普遍增加。脉络膜（−0.5222 µm/mm Hg，P < 0.001）和视网膜神经纤维层厚度（−0.0717 µm/mm Hg，P < 0.001）随IOP增加而显著变薄。随着年龄的增长，LC深度随IOP变化的幅度显著减小（所有参考平面P < 0.03）。LC深度随IOP的变化随着年龄的增长而降低，并且受到所选择的参考平面的显着影响，这凸显了需要标准化LC指标，以通过OCT成像正确跟踪ONH承重组织的渐进性重塑，并定义参考数据库。
To examine deformations of the optic nerve head (ONH) deep tissues in response to acute elevation of intraocular pressure (IOP). Research-consented brain-dead organ donors underwent imaging by spectral domain optical coherence tomography (OCT). OCT imaging was repeated while the eye was sequentially maintained at manometric pressures of 10, 30, and 50 mm Hg. Radial scans of the ONH were automatically segmented by deep learning and quantified in three dimensions by a custom algorithm. Change in lamina cribrosa (LC) depth and choroidal thickness was correlated with IOP and age by linear mixed-effect models. LC depth was computed against commonly utilized reference planes. Twenty-six eyes from 20 brain-dead organ donors (age range, 22–62 years; median age, 43 years) were imaged and quantified. LC depth measured against a reference plane based on Bruch's membrane (BM), BM opening, and an anterior sclera canal opening plane showed both a reduction and an increase in LC depth with IOP elevation. LC depth universally increased in depth when measured against a sclera reference plane. Choroidal (−0.5222 µm/mm Hg, P < 0.001) and retinal nerve fiber layer thickness (−0.0717 µm/mm Hg, P < 0.001) significantly thinned with increasing IOP. The magnitude of LC depth change with IOP was significantly smaller with increasing age (P < 0.03 for all reference planes). LC depth changes with IOP reduce with age and are significantly affected by the reference plane of choice, which highlights a need for standardizing LC metrics to properly follow progressive remodeling of the loadbearing tissues of the ONH by OCT imaging and for the definition of a reference database.
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影响因子：
3.5
作者：
Fazio, Massimo A.;Grytz, Rafael;Morris, Jeffrey S.;Bruno, Luigi;Gardiner, Stuart K.;Girkin, Christopher A.;Downs, J. Crawford
通讯作者：
Downs, J. Crawford
青光眼患者的多头表盘对圆形乳头结构和微脉管系统的影响。
影响因子：
2.9
作者：
Kamalipour, Alireza;Moghimi, Sasan;Inpirom, Veronica R.;Mahmoudinezhad, Golnoush;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.
影响因子：
4.6
作者：
Bruno, Luigi;Bianco, Gianfranco;Fazio, Massimo A.
通讯作者：
Fazio, Massimo A.
影响因子：
8.8
作者：
DeVita, MA;Wicclair, M;Schold, C
通讯作者：
Schold, C
影响因子：
3.4
作者：
Burgoyne, Claude F.
通讯作者：
Burgoyne, Claude F.