Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.
Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.
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青光眼患者的多头表盘对圆形乳头结构和微脉管系统的影响。
DOI：
10.1016/j.ogla.2022.05.004
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发表时间：
2022-11
影响因子：
2.9
通讯作者：
Weinreb, Robert N.
中科院分区：
文献类型：
--
作者：
Kamalipour, Alireza;Moghimi, Sasan;Inpirom, Veronica R.;Mahmoudinezhad, Golnoush;Weinreb, Robert N.
使用光学相干断层扫描血管造影 (OCTA) 评估多压力转盘 (MPD) 引起的压力变化对青光眼患者周围视乳头视网膜神经纤维层 (RNFL) 和毛细血管密度 (CD) 测量的影响。前瞻性介入研究 24 名原发性开角型青光眼患者 每名患者的一只眼睛接受 MPD 负压应用。 MPD 通过在放置在眼睛上方的护目镜室内产生负压真空来改变相对于大气压力的眼内压 (IOP)。每个参与者在 5 mmHg 的不同负压增量下接受视神经头的连续 HD OCTA 成像 (Angiovue)，从 0 mmHg 到 20 mmHg，然后返回到基线。在每个目标压力下持续负压 2 分钟后采集图像，以稳定视网膜结构和微脉管系统。使用原生 Angiovue 软件自动计算 RNFL 厚度和 CD 测量值，然后导出进行分析。通过重复测量的线性混合效应模型评估不同负压水平对乳头周围 RNFL 厚度和 CD 测量的影响。平均 (±SD) 年龄为 71.0 (±7.8) 岁，基线 IOP 为 17.5 (±3.6) mmHg，平均 24-2 平均偏差为 -2.80 (±2.55) dB。连续的乳头周围 CD 测量显示，从不施加负压的基线到施加 20 mmHg 的最大负压，剂量依赖性增加具有统计学意义（差异：2.27%，P = 0.010）。当负压降低至基线时，CD 测量值对称地下降。 10 mmHg、15 mmHg 和 20 mmHg 目标负压下的环乳头 CD 测量值显着高于基线测量值（所有 P < 0.05）。在不同负压水平下，周围乳头 RNFL 厚度保持不变。环乳头 CD 测量结果显示，随着负压的诱导，剂量依赖性增加，而 RNFL 厚度测量结果保持不变。本研究发现，使用多压转盘诱导负眼周压后，视乳头周围毛细血管密度呈现剂量反应增加，而视网膜神经纤维层厚度保持不变。
To evaluate the effects of Multi-Pressure Dial (MPD) induced pressure changes on circumpapillary retinal nerve fiber layer (RNFL) and capillary density (CD) measurements in glaucoma patients using Optical Coherence Tomography Angiography (OCTA). Prospective interventional study Twenty-four patients with primary open angle glaucoma One eye of each patient underwent negative pressure application with the MPD. The MPD alters intraocular pressure (IOP) relative to atmospheric pressure by generating a negative pressure vacuum within a goggle chamber that is placed over the eye. Each participant underwent serial HD OCTA imaging (Angiovue) of the optic nerve head at different negative pressure increments of 5 mmHg, starting from 0 mmHg to 20 mmHg and then returning to baseline. Images were acquired after 2 minutes of sustained negative pressure at each target pressure to allow for stabilization of the retinal structures and microvasculature. RNFL thickness and CD measurements were automatically calculated using the native Angiovue software and then exported for analysis. The influence of different levels of negative pressure on circumpapillary RNFL thickness and CD measurements assessed by a linear mixed effects model with repeated measures. Mean (±SD) age was 71.0 (±7.8) years, baseline IOP was 17.5 (±3.6) mmHg, and there was a mean 24–2 mean deviation of −2.80 (±2.55) dB. Serial circumpapillary CD measurements showed a statistically significant dose-dependent increase from baseline without negative pressure application to the maximum negative pressure application of 20 mmHg [difference: 2.27%, P = 0.010]. CD measurements then decreased symmetrically when lowering the negative pressure to baseline. Circumpapillary CD measurements at target negative pressures of 10 mmHg, 15 mmHg, and 20 mmHg were significantly higher than the baseline measurements (all P < 0.05). Circumpapillary RNFL thickness remained the same throughout different levels of negative pressure. Circumpapillary CD measurements showed a dose-dependent increase with the induction of negative pressure while RNFL thickness measurements remained unchanged. This study found that circumpapillary capillary density shows a dose-response increase after the induction of negative periocular pressure using multi-pressure dial while retinal nerve fiber layer thickness remains unchanged.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
4.6
作者：
Liu L;Takusagawa HL;Greenwald MF;Wang J;Alonzo B;Edmunds B;Morrison JC;Tan O;Jia Y;Huang D
通讯作者：
Huang D
DOI：
10.1111/j.1600-0420.2005.00567.x
发表时间：
2005-12-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Martínez, A;Sánchez, M
通讯作者：
Sánchez, M
影响因子：
9.1
作者：
Liu, Xiangxiang;Khodeiry, Mohamed M.;Wang, Ningli
通讯作者：
Wang, Ningli