Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.
Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.
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DOI：
10.1371/journal.pone.0122417
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Maghrabi IA
中科院分区：
文献类型：
--
作者：
Arab HH;Salama SA;Omar HA;Arafa el-SA;Maghrabi IA
饮酒通常与胃粘膜损伤有关，包括胃溃疡。Diosmin(DIO)是一种天然柑橘类黄酮，具有显著的抗氧化和抗炎功能，可保护其免受心脏、肝脏和肾脏的损伤。然而，其对胃溃疡的影响尚未阐明。因此，本研究旨在探讨DIO对大鼠乙醇性胃损伤的潜在保护作用。DIO(100 mg/kg，P.O.)减轻酒精性胃黏膜损伤的严重程度，表现为溃疡指数(UI)评分、胃损伤面积、组织病理学异常和白细胞侵袭。这些作用类似于参考抗溃疡药物硫糖铝的作用。DIO通过抑制髓过氧化物酶和肿瘤坏死因子-α水平以及核因子-kappaB(NF-αB)p65的表达来抑制胃炎症。它还能提高抗炎白介素10(IL-10)水平。同时，DIO通过抑制脂质过氧化，同时提高谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GPX)和总抗氧化能力(TAC)来抑制胃氧化应激。在胃粘膜细胞凋亡方面，DIO抑制caspase-3活性和细胞色素C(CytC)，增强抗凋亡B细胞淋巴瘤-2(Bcl2)，有利于细胞存活。这些有利作用与胃黏膜细胞保护性前列腺素E_2(PGE_2)和一氧化氮(NO)上调有关。综上所述，这些发现强调了DIO在酒精性胃损伤中的胃保护作用，这种保护作用是通过协调的多管齐下的作用来实现的，包括抑制胃炎症、氧化应激和细胞凋亡，以及增强抗氧化剂和细胞保护防御。
Alcohol consumption has been commonly associated with gastric mucosal lesions including gastric ulcer. Diosmin (DIO) is a natural citrus flavone with remarkable antioxidant and anti-inflammatory features that underlay its protection against cardiac, hepatic and renal injuries. However, its impact on gastric ulcer has not yet been elucidated. Thus, the current study aimed to investigate the potential protective effects of DIO against ethanol-induced gastric injury in rats. Pretreatment with DIO (100 mg/kg p.o.) attenuated the severity of ethanol gastric mucosal damage as evidenced by lowering of ulcer index (UI) scores, area of gastric lesions, histopathologic aberrations and leukocyte invasion. These actions were analogous to those exerted by the reference antiulcer sucralfate. DIO suppressed gastric inflammation by curbing of myeloperoxidase (MPO) and tumor necrosis factor-α (TNF-α) levels along with nuclear factor kappa B (NF-κB) p65 expression. It also augmented the anti-inflammatory interleukin-10 (IL-10) levels. Meanwhile, DIO halted gastric oxidative stress via inhibition of lipid peroxides with concomitant enhancement of glutathione (GSH), glutathione peroxidase (GPx) and the total antioxidant capacity (TAC). With respect to gastric mucosal apoptosis, DIO suppressed caspase-3 activity and cytochrome C (Cyt C) with enhancement of the anti-apoptotic B cell lymphoma-2 (Bcl-2) in favor of cell survival. These favorable actions were associated with upregulation of the gastric cytoprotective prostaglandin E2 (PGE2) and nitric oxide (NO). Together, these findings accentuate the gastroprotective actions of DIO in ethanol gastric injury which were mediated via concerted multi-pronged actions, including suppression of gastric inflammation, oxidative stress and apoptosis besides boosting of the antioxidant and the cytoprotective defenses.
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影响因子：
4.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
Abdulla, Mahmood Ameen
影响因子：
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作者：
Golbabapour S;Hajrezaie M;Hassandarvish P;Abdul Majid N;Hadi AH;Nordin N;Abdulla MA
通讯作者：
Abdulla MA
影响因子：
2.3
作者：
GUSLANDI M
通讯作者：
GUSLANDI M