Evaluating clinical characteristics studies produced early in the Covid-19 pandemic: A systematic review.
Evaluating clinical characteristics studies produced early in the Covid-19 pandemic: A systematic review.
复制标题
DOI：
10.1371/journal.pone.0251250
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Olliaro P
中科院分区：
文献类型：
--
作者：
Manoharan L;Cattrall JWS;Harris C;Newell K;Thomson B;Pritchard MG;Bannister PG;Sigfrid L;Solomon T;Horby PW;Carson G;Olliaro P
临床特征研究在帮助为研究、诊断和临床管理工作提供信息方面至关重要，特别是在大流行的早期。本系统性综述总结了关于入院患者临床特征的早期文献，并评估了大流行初期阶段产生的证据质量。检索了MEDLINE、EMBASE和Global Health数据库中2020年1月1日至2020年4月28日发表的研究。纳入了至少100名任何年龄的新型冠状病毒住院患者的研究。关于临床特征的数据由两位综述作者独立提取。研究设计特定的关键评价工具用于评价纳入的研究：队列和横断面研究的纽卡斯尔渥太华量表，病例系列的Joanna Briggs研究所检查表和评估随机试验偏倚风险的科克伦协作工具。搜索产生了78项研究，提供了77，443人的数据。大多数研究（82%）在中国进行。没有研究包括来自低收入和中等收入国家的患者。纳入研究的总体质量为低至中等，大多数研究不包括对照组。发烧和咳嗽是大流行早期最常报告的症状。实验室检查和影像学表现多样，淋巴细胞减少和毛玻璃样影分别是最常见的表现。儿童和弱势人群的临床数据有限。早期的Covid-19文献具有中度至高度的偏倚风险，并提出了几个方法学问题。早期临床特征研究应旨在纳入不同的高危人群，包括非医院环境中的患者。大流行准备需要收集工具，以确保观察性研究在方法上是可靠的，并将有助于在大流行早期产生高质量的数据，以指导临床实践和公共卫生政策。可在https://osf.io/mpafn上获得
Clinical characterisation studies have been essential in helping inform research, diagnosis and clinical management efforts, particularly early in a pandemic. This systematic review summarises the early literature on clinical characteristics of patients admitted to hospital, and evaluates the quality of evidence produced during the initial stages of the pandemic. MEDLINE, EMBASE and Global Health databases were searched for studies published from January 1st 2020 to April 28th 2020. Studies which reported on at least 100 hospitalised patients with Covid-19 of any age were included. Data on clinical characteristics were independently extracted by two review authors. Study design specific critical appraisal tools were used to evaluate included studies: the Newcastle Ottawa scale for cohort and cross sectional studies, Joanna Briggs Institute checklist for case series and the Cochrane collaboration tool for assessing risk of bias in randomised trials. The search yielded 78 studies presenting data on 77,443 people. Most studies (82%) were conducted in China. No studies included patients from low- and middle-income countries. The overall quality of included studies was low to moderate, and the majority of studies did not include a control group. Fever and cough were the most commonly reported symptoms early in the pandemic. Laboratory and imaging findings were diverse with lymphocytopenia and ground glass opacities the most common findings respectively. Clinical data in children and vulnerable populations were limited. The early Covid-19 literature had moderate to high risk of bias and presented several methodological issues. Early clinical characterisation studies should aim to include different at-risk populations, including patients in non-hospital settings. Pandemic preparedness requires collection tools to ensure observational studies are methodologically robust and will help produce high-quality data early on in the pandemic to guide clinical practice and public health policy. Available at https://osf.io/mpafn
登录
查看更多内容
影响因子：
168.9
作者：
Chopra, Mickey;Mason, Elizabeth;Bhutta, Zulfiqar A.
通讯作者：
Bhutta, Zulfiqar A.
影响因子：
2.1
作者：
Fan, Na;Fan, WenHui;Liang, Yi
通讯作者：
Liang, Yi
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
影响因子：
28.2
作者：
Chen, Jun;Qi, Tangkai;Lu, Hongzhou
通讯作者：
Lu, Hongzhou
DOI：
10.15585/mmwr.mm6915e6
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team