Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets

Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets
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双壳 CdTe/CdS/ZnS 量子点作为荧光探针测定富马酸喹硫平片中的喹硫平

DOI:
10.1039/c3ay41580e
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发表时间:
2014
期刊:
影响因子:
3.1
通讯作者:
Hu Qin
Hu Qin
中科院分区:
化学3区
文献类型:
--
作者:
Sun Xuan;Liu Liping;Zhou Ping;Hu Qin

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提出了一种简单、灵敏、方便的荧光猝灭方法。采用一锅法在水溶液中制备了CdTe/CdS/ZnS量子点,并通过吸收光谱、荧光光谱、X射线光电子能谱和透射电子显微镜对其进行了表征。在最佳条件下,F0/F与奎替鲁胺浓度的校准曲线在5-100 μM范围内呈线性关系,相关系数为0.9958。检测限为0.8 μM。用该方法测定富马酸喹替林片中喹替林的含量,结果与标示值相符。探讨了可能的荧光猝灭机理。
A simple, sensitive and convenient method based on the fluorescence quenching of double shell CdTe/CdS/ZnS quantum dots (QDs) by quetiapine was proposed. CdTe/CdS/ZnS QDs were synthesized by a one-pot capping method in aqueous solution and characterized by absorption spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy and transmission electron microscopy. Under optimal conditions, the calibration plot of F0/F versus the concentration of quetiapine was linear in the range of 5–100 μM with a correlation coefficient of 0.9958. The limit of detection was 0.8 μM. The concentration of quetiapine in quetiapine fumarate tablets was determined by the proposed method and the results agreed with the claimed values. The possible fluorescence quenching mechanism was discussed.
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