Indoor air pollution and risk of lung cancer among Chinese female non-smokers.
Indoor air pollution and risk of lung cancer among Chinese female non-smokers.
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DOI：
10.1007/s10552-012-0130-8
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发表时间：
2013-03
影响因子：
2.3
通讯作者：
Zhang, Zuo-Feng
中科院分区：
文献类型：
--
作者：
Mu, Lina;Liu, Li;Niu, Rungui;Zhao, Baoxing;Shi, Jianping;Li, Yanli;Swanson, Mya;Scheider, William;Su, Jia;Chang, Shen-Chih;Yu, Shunzhang;Zhang, Zuo-Feng
调查中国城市人群的室内颗粒物 (PM) 水平和各种室内空气污染暴露，并研究它们与肺癌风险的关系，重点关注不吸烟女性。我们在中国太原进行了一项病例对照研究，包括 399 例肺癌病例和 466 名对照者，其中 164 例病例和 218 名对照者是女性非吸烟者。使用颗粒质量监测仪测量室内 PM 浓度，包括 PM1、PM2.5、PM7、PM10 和 TSP。在调整年龄、教育程度、年收入和吸烟情况后，使用无条件逻辑回归模型计算优势比 (OR) 和 95% 置信区间。在不吸烟女性中，10年前，肺癌与多种室内空气污染源密切相关，包括工作时大量接触ETS（aOR=3.65）、频繁做饭（aOR=3.30）以及使用固体燃料做饭（aOR=4.08）和取暖（aOR煤炉=2.00）。与通风不良相关的住房特征，包括单层、窗户面积较小、没有独立厨房、没有通风设备以及很少打开窗户等，与肺癌有关。室内介质PM2.5浓度为68ug/m3，PM10为230ug/m3。冬季 PM 水平与烹饪、取暖和通风的固体燃料使用量密切相关。病例中的 PM1 水平比对照高出 3 倍多。 PM1 每增加 10 ug/m3，患肺癌的风险就会增加 45%。室内空气污染在中国不吸烟女性肺癌的发生中起着重要作用。
To investigate indoor particulate matter (PM) level and various indoor air pollution exposure, and to examine their relationships with risk of lung cancer in an urban Chinese population, with a focus on non-smoking women. We conducted a case-control study in Taiyuan, China, consisting of 399 lung cancer cases and 466 controls, of which 164 cases and 218 controls were female non-smokers. Indoor PM concentrations, including PM1, PM2.5, PM7, PM10 and TSP, were measured using a particle mass monitor. Unconditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals after adjusting for age, education, annual income and smoking. Among non-smoking women, lung cancer was strongly associated with multiple sources of indoor air pollution 10 years ago, including heavy exposure to ETS at work (aOR=3.65), high frequency of cooking (aOR=3.30), and solid fuel usage for cooking (aOR=4.08) and heating (aORcoal stove=2.00). Housing characteristics related to poor ventilation, including single-story, less window area, no separate kitchen, no ventilator and rarely having windows open, are associated with lung cancer. Indoor medium PM2.5 concentration was 68ug/m3, and PM10 was 230ug/m3. PM levels in winter are strongly correlated with solid fuel usage for cooking, heating and ventilators. PM1 levels in cases are more than 3-time higher than that in controls. Every 10 ug/m3 increase in PM1 is associated with 45% increased risk of lung cancer. Indoor air pollution plays an important role in the development of lung cancer among non-smoking Chinese women.
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影响因子：
168.9
作者：
Lin, Hsien-Ho;Murray, Megan;Cohen, Ted;Colijn, Caroline;Ezzati, Majid
通讯作者：
Ezzati, Majid
影响因子：
5.3
作者：
Li, Mingchuan;Yin, Zhihua;Zhou, Baosen
通讯作者：
Zhou, Baosen
影响因子：
2.6
作者：
Li, Yanli;Chang, Shen-Chih;Goldstein, Binh Y.;Scheider, William L.;Cai, Lin;You, Nai-Chieh Y.;Tarleton, Heather P.;Ding, Baoguo;Zhao, Jinkou;Wu, Ming;Jiang, Qingwu;Yu, Shunzhang;Rao, Jianyu;Lu, Qing-Yi;Zhang, Zuo-Feng;Mu, Lina
通讯作者：
Mu, Lina
影响因子：
2.4
作者：
Galeone, Carlotta;Pelucchi, Claudio;Hu, Jinfu
通讯作者：
Hu, Jinfu
影响因子：
11.4
作者：
Hoh, Eunha;Hunt, Richard N.;Matt, Georg E.
通讯作者：
Matt, Georg E.