Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population.
Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population.
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DOI：
10.1016/j.canep.2011.01.005
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发表时间：
2011-08
影响因子：
2.6
通讯作者：
Mu, Lina
中科院分区：
文献类型：
--
作者：
Li, Yanli;Chang, Shen-Chih;Goldstein, Binh Y.;Scheider, William L.;Cai, Lin;You, Nai-Chieh Y.;Tarleton, Heather P.;Ding, Baoguo;Zhao, Jinkou;Wu, Ming;Jiang, Qingwu;Yu, Shunzhang;Rao, Jianyu;Lu, Qing-Yi;Zhang, Zuo-Feng;Mu, Lina
绿色茶已被发现具有抗炎，抗氧化和抗癌特性。本研究探讨了饮用绿色茶与肝细胞癌（HCC）的相关性及其与其他危险因素或保护因素以及炎症和氧化应激相关基因的单核苷酸多态性（SNP）的相互作用。在中国泰兴进行了一项基于人群的病例对照研究，包括204例原发性肝癌病例和415例健康对照。流行病学数据收集使用标准问卷。在UCLA分子流行病学实验室对炎症和代谢途径基因的SNP进行基因分型。进行逻辑回归以估计调整后的比值比和95%置信区间。较长的时间和大量的绿色茶消费与原发性肝癌呈负相关。饮用绿色茶超过30年的人与不饮用者相比风险最低（调整后OR = 0.44，95%CI：0.19-0.96）。在饮用绿色茶和饮酒之间观察到强烈的相互作用（调整的相互作用OR = 3.40，95%CI：1.26-9.16）。绿色茶饮料也被观察到对HBV/HCV感染、吸烟和炎症相关细胞因子（尤其是IL-10）的多态性具有潜在的影响。饮用绿色茶可以预防原发性HCC的发展。绿色茶对原发性肝癌与饮酒、HBV/HCV感染和炎症相关SNPs之间的关联的潜在影响被提出。
Green tea has been found to possess anti-inflammatory, anti-oxidative and anti-carcinogenic properties. The present study examines the association between green tea drinking and hepatocellular carcinoma (HCC) and its interactions with other risk or protective factors and single nucleotide polymorphisms (SNP) of inflammation and oxidative stress related genes. A population-based case-control study with 204 primary HCC cases and 415 healthy controls was conducted in Taixing, China. Epidemiological data were collected using a standard questionnaire. SNPs of genes of the inflammation and metabolic pathways were genotyped at the UCLA Molecular Epidemiology Laboratory. Logistic regression was performed to estimate adjusted odds ratios and 95% confidence intervals. Longer duration and larger quantities of green tea consumption were inversely associated with primary HCC. Individuals who drank green tea longer than 30 years were at lowest risk (adjusted OR = 0.44, 95% CI: 0.19-0.96) compared with non-drinkers. A strong interaction was observed between green tea drinking and alcohol consumption (adjusted OR for interaction = 3.40, 95% CI: 1.26-9.16). Green tea drinking was also observed to have a potential effect modification on HBV/HCV infection, smoking and polymorphisms of inflammation related cytokines, especially for IL-10. Green tea consumption may protect against development of primary HCC. Potential effect modifications of green tea on associations between primary HCC and alcohol drinking, HBV/HCV infection, and inflammation-related SNPs were suggested.
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影响因子：
4.7
作者：
Hoshiyama Y;Kawaguchi T;Miura Y;Mizoue T;Tokui N;Yatsuya H;Sakata K;Kondo T;Kikuchi S;Toyoshima H;Hayakawa N;Tamakoshi A;Yoshimura T;JACC Study Group
通讯作者：
JACC Study Group
影响因子：
3.8
作者：
Inoue, Manami;Kurahashi, Norie;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
9.7
作者：
Inoue, M;Tajima, K;Tominaga, S
通讯作者：
Tominaga, S
影响因子：
6.1
作者：
Cabrera, C;Giménez, R;López, MC
通讯作者：
López, MC
DOI：
10.1111/j.1749-6632.2009.03704.x
发表时间：
2009-01-01
期刊：
STEROID ENZYMES AND CANCER
影响因子：
--
作者：
Berasain, C.;Castillo, J.;Avila, M. A.
通讯作者：
Avila, M. A.