Synthesis and characterization of dual stimuli responsive macromers based on poly(N-isopropylacrylamide) and poly(vinylphosphonic acid).
Synthesis and characterization of dual stimuli responsive macromers based on poly(N-isopropylacrylamide) and poly(vinylphosphonic acid).
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DOI：
10.1021/bm9014182
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发表时间：
2010-03-08
影响因子：
6.2
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Kretlow, James D.;Hacker, Michael C.;Klouda, Leda;Ma, Brandy B.;Mikos, Antonios G.
刺激响应材料在生物应用中具有很大的前景，因为它们可以对生理刺激的变化做出反应以产生期望的效果。通过自由基聚合，由N-异丙基丙烯酰胺、季戊四醇二丙烯酸酯单硬脂酸酯、丙烯酸2-羟乙酯和乙烯基膦酸合成刺激响应性大分子单体，其被设计为响应于37 °C或37 °C附近的温度变化和二价阳离子的存在。将单体以接近摩尔进料比的比例掺入大分子单体中，并且大分子单体在正常体温（36.2 - 40.5 °C）附近经历热凝胶化，如通过流变学和差示扫描量热法测定的。含有乙烯基膦酸的大分子单体与溶液中的钙离子相互作用，显示出降低的溶胶-凝胶转变温度（在100 mM CaCl 2中为27.6 - 34.4 °C），其中对于具有较高相对乙烯基膦酸含量的大分子单体观察到更大幅度的降低。临界胶束浓度也以剂量依赖性的方式降低，增加乙烯基膦酸掺入的溶液中与氯化钙，但不是在溶液中与NaCl。这些双重响应的大分子单体允许检查增加大分子单体中乙烯基膦酸含量的效果，由于大分子单体在生理温度和钙浓度下的响应性，大分子单体在生物学应用如药物和细胞递送或组织工程中有希望。
Stimulus responsive materials hold great promise in biological applications as they can react to changes in physiological stimuli to produce a desired effect. Stimulus responsive macromers designed to respond to temperature changes at or around 37 °C and the presence of divalent cations were synthesized from N-isopropylacrylamide, pentaerythritol diacrylate monostearate, 2-hydroxyethyl acrylate, and vinylphosphonic acid by free radical polymerization. Monomers were incorporated into the macromers in ratios approximating the molar feed ratios, and macromers underwent thermogelation around normal body temperature (36.2 – 40.5 °C) as determined by rheology and differential scanning calorimetry. Macromers containing vinylphosphonic acid interacted with calcium ions in solution, displaying decreased sol-gel transition temperatures (27.6 – 34.4 °C in 100 mM CaCl2), with decreases of greater magnitude observed for macromers with higher relative vinylphosphonic acid content. Critical micellar concentrations also decreased in a dose-dependent manner with increased vinylphosphonic acid incorporation in solutions with CaCl2 but not in solutions with NaCl. These dually responsive macromers allow examination of the effect of increasing vinylphosphonic acid content in a macromer which holds promise in biological applications such as drug and cell delivery or tissue engineering due to the macromer responsiveness at physiological temperatures and concentrations of calcium.
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影响因子：
10.8
作者：
Anseth, KS;Metters, AT;Bowman, CN
通讯作者：
Bowman, CN
DOI：
10.1073/pnas.0306141101
发表时间：
2004-04-06
影响因子：
11.1
作者：
Dvorak, MM;Siddiqua, A;Riccardi, D
通讯作者：
Riccardi, D
影响因子：
3.5
作者：
Chattopadhyay, A;Harikumar, KG
通讯作者：
Harikumar, KG
影响因子：
4
作者：
Dvorak, MM;Riccardi, D
通讯作者：
Riccardi, D
影响因子：
6.2
作者：
Declercq, HA;Gorski, TL;Cornelissen, MJ
通讯作者：
Cornelissen, MJ