Interaction of the Lyme disease spirochete with its tick vector.
Interaction of the Lyme disease spirochete with its tick vector.
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DOI：
10.1111/cmi.12609
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发表时间：
2016-07
影响因子：
3.4
通讯作者：
Samuels DS
中科院分区：
文献类型：
--
作者：
Caimano MJ;Drecktrah D;Kung F;Samuels DS
伯氏疏螺旋体（Borrelia burgdorferi）是莱姆病（以及密切相关的基因种）的病原体，属于分支较深的螺旋体门。这种细菌在自然界中维持在一种兽疫循环中，其中包括从蜱虫媒介传播到脊椎动物宿主，以及从脊椎动物宿主获得蜱虫媒介。在其节肢动物寄居期间，伯氏疏螺旋体面临各种压力，包括营养剥夺。在这里，我们回顾了一些促进伯氏疏螺旋体在蜱体内持续存在、维持和传播的螺旋体因素，然后重点介绍了可用碳水化合物的利用以及为适应血食之间的严峻环境而启动的精细调节系统，以及在细菌穿越其地方病循环时发出物种转变信号的调节系统。螺旋体将它们的碳和能量来源从脊椎动物的葡萄糖转移到蜱虫的甘油。在限制营养条件下的生存调节需要RelBbu控制四磷酸鸟苷和五磷酸鸟苷（统称为(p)ppGpp）的报警水平，而蜱-脊椎动物界面的调节以及对血液的保护反应的调节需要双组分系统Hk1/Rrp1激活第二信使环二聚体- gmp （c-di-GMP）的产生。
Borrelia burgdorferi , the causative agent of Lyme disease (along with closely related genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in nature in an enzootic cycle that involves transmission from a tick vector to a vertebrate host and acquisition from a vertebrate host to a tick vector. During its arthropod sojourn, B. burgdorferi faces a variety of stresses, including nutrient deprivation. Here, we review some of the spirochetal factors that promote persistence, maintenance and dissemination of B. burgdorferi in the tick, and then focus on the utilization of available carbohydrates as well as the exquisite regulatory systems invoked to adapt to the austere environment between blood meals and to signal species transitions as the bacteria traverse their enzootic cycle. The spirochetes shift their source of carbon and energy from glucose in the vertebrate to glycerol in the tick. Regulation of survival under limiting nutrients requires the classic stringent response in which RelBbu controls the levels of the alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively termed (p)ppGpp), while regulation at the tick–vertebrate interface as well as regulation of protective responses to the blood meal require the two-component system Hk1/Rrp1 to activate production of the second messenger cyclic-dimeric-GMP (c-di-GMP).
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影响因子：
3.1
作者：
Caimano, Melissa J.;Dunham-Ems, Star;Radolf, Justin D.
通讯作者：
Radolf, Justin D.
影响因子：
3.1
作者：
Bugrysheva, JV;Bryksin, AV;Cabello, FC
通讯作者：
Cabello, FC
影响因子：
4.1
作者：
Fingerle, Volker;Goettner, Gereon;Schulte-Spechtel, Ulrike
通讯作者：
Schulte-Spechtel, Ulrike
影响因子：
3.7
作者：
Corona A;Schwartz I
通讯作者：
Schwartz I
影响因子：
158.5
作者：
BENACH, JL;BOSLER, EM;KASLOW, RA
通讯作者：
KASLOW, RA