Time Trends in the Incidence of Parkinson Disease.
Time Trends in the Incidence of Parkinson Disease.
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DOI：
10.1001/jamaneurol.2016.0947
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发表时间：
2016-08-01
期刊：
影响因子：
29
通讯作者：
Rocca, Walter A.
中科院分区：
文献类型：
--
作者：
Savica, Rodolfo;Grossardt, Brandon R.;Bower, James H.;Ahlskog, J. Eric;Rocca, Walter A.
帕金森病和帕金森病 (PD) 的发病率随时间的变化仍不确定。旨在调查 30 年来特定地理区域的美国人口中帕金森病和帕金森病发病率的长期趋势（周期效应）和出生队列趋势。我们使用罗切斯特流行病学项目 (REP) 的医疗记录链接系统来识别明尼苏达州奥姆斯特德县 1976 年至 2005 年间 PD 和其他类型帕金森病的发病病例。所有病例均由运动障碍专家通过审查系统内完整的医疗记录，使用明确的标准进行分类。 30 年来帕金森病和 PD 的发病率。我们使用负二项式回归模型测试了长期趋势（周期效应），并使用年龄-周期队列模型测试了出生队列效应。 30 年来，男性帕金森病（RR 1.17 每十年，95% CI 1.03-1.33）和 PD（RR 1.24 每十年，95% CI 1.08-1.43）的总体发病率显着增加。这些趋势主要是由老年群体推动的。特别是，对于 70 岁以上的男性，帕金森病（RR 1.24 每十年，95% CI 1.07-1.44）和 PD（RR 1.35 每十年，95% CI 1.10-1.65）的发病率均增加。对于整体女性或年龄层的女性来说，长期趋势并不显着。我们观察到 1920 年队列（1915-1924 年）出生的男性和女性的风险均增加。然而，这种出生队列效应仅对帕金森病且仅在男性中显着。我们的研究表明，近几十年来，帕金森病和帕金森病的发病率可能有所增加，尤其是在 70 岁及以上的男性中。这些趋势可能与20世纪下半叶吸烟行为的巨大变化有关。然而，这些趋势可能是虚假的，需要在其他人群中得到证实。
Changes over time in the incidence of parkinsonism and Parkinson’s disease (PD) remain uncertain. To investigate secular trends (period effects) and birth cohort trends in the incidence of parkinsonism and PD over 30 years in a geographically defined American population. We used the medical records-linkage system of the Rochester Epidemiology Project (REP) to identify incidence cases of PD and other types of parkinsonism in Olmsted County, MN, from 1976 to 2005. All cases were classified by a movement disorder specialist using defined criteria through the review of the complete medical records within the system. Incidence rates of parkinsonism and PD over 30 years. We tested for secular trends (period effects) using negative binomial regression models and for birth cohort effects using age-period-cohort models. The overall incidence rates increased significantly over 30 years in men for both parkinsonism (RR 1.17 per decade, 95% CI 1.03-1.33) and PD (RR 1.24 per decade, 95% CI 1.08-1.43). These trends were driven primarily by the older age groups. In particular, for men ≥ 70 years, incidence rates increased for both parkinsonism (RR 1.24 per decade, 95% CI 1.07-1.44) and PD (RR 1.35 per decade, 95% CI 1.10-1.65). The secular trends were not significant for women overall or in age strata. We observed an increased risk for both men and women born in the 1920 cohort (1915-1924). However, this birth cohort effect was significant only for PD and only in men. Our study suggests that the incidence of parkinsonism and PD may have increased in recent decades particularly in men 70 years old and older. These trends may be related to the dramatic changes in smoking behavior that took place in the second half of the 20th century. However, the trends could be spurious, and need to be confirmed in other populations.
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影响因子：
3.5
作者：
Savica, Rodolfo;Grossardt, Brandon R.;Bower, James H.;Ahlskog, J. Eric;Rocca, Walter A.
通讯作者：
Rocca, Walter A.
影响因子：
10.4
作者：
Bronstein, Jeff;Carvey, Paul;Chen, Honglei;Cory-Slechta, Deborah;DiMonte, Donato;Duda, John;English, Paul;Goldman, Samuel;Grate, Stephen;Hansen, Johnni;Hoppin, Jane;Jewell, Sarah;Kamel, Freya;Koroshetz, Walter;Langston, James W.;Logroscino, Giancarlo;Nelson, Lorene;Ravina, Bernard;Rocca, Walter;Ross, George W.;Schettler, Ted;Schwarzschild, Michael;Scott, Bill;Seegal, Richard;Singleton, Andrew;Steenland, Kyle;Tanner, Caroline M.;Van Den Eeden, Stephen;Weisskopf, Marc
通讯作者：
Weisskopf, Marc
影响因子：
9.9
作者：
Bower, JH;Maraganore, DM;Rocca, WA
通讯作者：
Rocca, WA
影响因子：
9.9
作者：
Rocca, WA;Bower, JH;Maraganore, DM
通讯作者：
Maraganore, DM
影响因子：
6
作者：
Horsfall, Laura;Petersen, Irene;Schrag, Anette
通讯作者：
Schrag, Anette