Risk factors for Parkinson's disease may differ in men and women: an exploratory study.
Risk factors for Parkinson's disease may differ in men and women: an exploratory study.
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DOI：
10.1016/j.yhbeh.2012.05.013
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发表时间：
2013-02
影响因子：
3.5
通讯作者：
Rocca, Walter A.
中科院分区：
文献类型：
--
作者：
Savica, Rodolfo;Grossardt, Brandon R.;Bower, James H.;Ahlskog, J. Eric;Rocca, Walter A.
关键词：
虽然一些环境和遗传风险或保护因素与帕金森病（PD）有关，但它们的相互作用总体上以及男性和女性分别仍然未知。我们使用罗切斯特流行病学项目的病历联系系统，确定了1976年至1995年在明尼苏达州奥姆斯特德县发生PD的196例受试者。每个发病病例的年龄（±1岁）和性别与一般人群对照相匹配。我们考虑了以下12个风险或保护因素：头部创伤、农药使用、免疫性疾病、贫血、子宫切除术（仅女性）、吸烟、咖啡消费和教育的个人史;帕金森氏症、特发性震颤、痴呆或精神疾病的家族史。我们使用递归分区分析来探索整体和男性和女性分别的相互作用，并使用逻辑回归分析来测试相互作用。在整个组中，我们观察到贫血，缺乏咖啡消费（从未与曾经）和头部创伤的独立影响;然而，男性和女性的研究结果不同。在男性中，我们观察到缺乏咖啡消费（从不与曾经）、头部创伤和杀虫剂使用的独立影响，以及免疫疾病和痴呆症家族史之间的协同相互作用。相比之下，在女性中，贫血是最重要的因素，我们观察到贫血和高等教育之间的协同作用。PD的风险因素及其相互作用在男性和女性中可能不同。
Although several environmental and genetic risk or protective factors have been associated with Parkinson’s disease (PD), their interactions overall and in men and women separately remain unknown. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We considered the following 12 risk or protective factors: personal history of head trauma, pesticide use, immunologic diseases, anemia, hysterectomy (in women only), cigarette smoking, coffee consumption, and education; and family history of parkinsonism, essential tremor, dementia, or psychiatric disorders. We used recursive partitioning analyses to explore interactions overall and in men and women separately and used logistic regression analyses to test for interactions. In the overall group, we observed the independent effects of anemia, lack of coffee consumption (never vs. ever), and head trauma; however, the findings were different in men and women. In men, we observed the independent effects of lack of coffee consumption (never vs. ever), head trauma, and pesticide use, and a suggestive synergistic interaction between immunologic diseases and family history of dementia. By contrast, in women, anemia was the most important factor and we observed a suggestive synergistic interaction between anemia and higher education. Risk factors for PD and their interactions may differ in men and women.
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影响因子：
9.9
作者：
Frigerio, R;Elbaz, A;Rocca, WA
通讯作者：
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影响因子：
9.9
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Bower, JH;Maraganore, DM;Rocca, WA
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作者：
Arabia, Gennarina;Grossardt, Brandon R.;Rocca, Walter A.
通讯作者：
Rocca, Walter A.
影响因子：
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通讯作者：
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影响因子：
9.9
作者：
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通讯作者：
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