Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
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DOI：
10.1371/journal.pone.0109131
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Liang H
中科院分区：
文献类型：
--
作者：
Geng P;Zhao X;Xiang L;Liao Y;Wang N;Ou J;Xie G;Liu C;Li J;Li H;Zeng R;Liang H
先前关于CD86多态在癌症中的作用的研究(rs1129055和rs17281995)未能提供令人信服的证据。这项研究的目的是通过荟萃分析来研究常见的基因多态在癌症风险中的作用。通过检索PUBMED、EMBASE、CNKI和WANFANG等检索词86/CD86/B7-2/polymorphism/polymorphisms/cancer，，分别检索到rs1129055(2137人)和rs17281995(2856人)的4篇研究。通过优势比(OR)和95%可信区间(95%CI)来评估癌症风险。总体而言，我们观察到与rs1129055相关的癌症风险显著降低。与AA基因携带者相比，GG基因携带者罹患癌症的风险降低62%(GG对AA：OR为0.62；95%CI为0.49~0.79；Phet.，0.996)。在G对A等位基因模型和GG对GA+AA遗传模型中也表现出类似的效应(OR，0.83；95%CI，0.74-0.93；Phet.，0.987；OR，0.63；95%CI，0.50-0.79；Phet.，0.973)。此外，我们还发现rs17281995对总体癌症风险有重要影响(CC与GG：OR 2.38；95%CI，1.43-3.95；Phet.，0.433；C与G：OR，1.23；95%CI，1.06-1.43；Phet.，0.521；CC与GC+GG：OR，2.38；95%CI，1.45-3.93；Phet.，0.443)。这种关联在高加索人和结直肠癌中也观察到了。在这项荟萃分析中没有发现明显的发表偏倚。这些数据表明，rs1129055可能对亚洲人的癌症风险具有保护作用，rs17281995可能导致癌症的风险，特别是高加索人的结直肠癌。
Previous studies concerning the role of CD86 polymorphisms (rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this study was to investigate the role of common polymorphisms in the risk of cancer by meta-analysis. By using the search terms Cluster of Differentiation 86/CD86/B7-2/polymorphism/polymorphisms/cancer, we searched PubMed, Embase, CNKI, and Wanfang and identified four studies for rs1129055 (2137 subjects) and rs17281995 (2856 subjects) respectively. Cancer risk was estimated by odds ratio (OR) and 95% confidence interval (95% CI). Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49–0.79; Phet., 0.996). Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74–0.93; Phet., 0.987; OR, 0.63; 95% CI, 0.50–0.79; Phet., 0.973). In addition, we found genotypes of rs17281995 had a major effect on overall cancer risk (CC versus GG: OR, 2.38; 95% CI, 1.43–3.95; Phet., 0.433; C versus G: OR, 1.23; 95% CI, 1.06–1.43; Phet., 0.521; CC versus GC+GG: OR, 2.38; 95% CI, 1.45–3.93; Phet., 0.443). The association was also observed in Caucasians and colorectal cancer. No obvious publication bias was detected in this meta-analysis. These data reveal that rs1129055 may have protective effects on cancer risk in Asians and that rs17281995 is likely to contribute to risk of cancer, particularly colorectal cancer in Caucasians.
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影响因子：
14.9
作者：
Ramensky, V;Bork, P;Sunyaev, S
通讯作者：
Sunyaev, S
影响因子：
3.1
作者：
Pan, Xin-Min;Gao, Lin-Bo;Zhang, Lin
通讯作者：
Zhang, Lin
DOI：
10.1007/s00432-012-1289-9
发表时间：
2012-12-01
影响因子：
3.6
作者：
Xiang, Honggang;Zhao, Wei;Hu, Zhiqian
通讯作者：
Hu, Zhiqian
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.7
作者：
Landi, Debora;Gemignani, Federica;Landi, Stefano
通讯作者：
Landi, Stefano