Accurate decoding of reaching movements from field potentials in the absence of spikes.
Accurate decoding of reaching movements from field potentials in the absence of spikes.
复制标题
DOI：
10.1088/1741-2560/9/4/046006
复制
发表时间：
2012-08
影响因子：
4
通讯作者：
Slutzky MW
中科院分区：
文献类型：
--
作者：
Flint RD;Lindberg EW;Jordan LR;Miller LE;Slutzky MW
最近人们对脑机接口 (BMI) 的兴趣激增，刺激了针对所需应用最佳选择输入信号源的研究。具有最高带宽的信号（单个神经元动作电位或尖峰）通常在植入皮质内电极后几年内很难记录。幸运的是，皮质内记录的场电位（局部场电位，LFP）、皮质表面（皮质电图，ECoG）和硬脑膜表面（硬膜外，EFP）也被证明包含有关运动的重要信息。然而，这些信号的相对性能尚未直接比较。此外，虽然人们普遍假设，但尚未证明这些场电位信号比尖峰记录更持久。本研究的目的是解决这两个问题。我们评估了初级运动皮层 (M1) 中按顺序记录的 EFP、LFP 和尖峰的离线解码性能，评估了它们解码到达运动目标以及终点轨迹的能力。我们还检查了 LFP 在未记录尖峰的电极上的解码性能，并将其与记录尖峰时的性能进行比较。在整个研究过程中，其他一些电极上仍然存在尖峰。我们表明，LFP 在解码速度方面的表现几乎与峰值一样，但在解码位置和目标分类方面稍差。 EFP 的表现略逊于人类 ECoG 的表现。我们还提供了证据，证明无论是否能够在同一电极上同时记录尖峰，LFP 中的运动相关信息仍然很高。这是第一项提供证据的研究，证明 LFP 在同一电极上没有尖峰的情况下仍能保留有关运动的信息。这些结果表明，在尖峰记录丢失后，LFP 确实可能保留信息，从而为 BMI 提供强大、准确的信号源。
The recent explosion of interest in brain-machine interfaces (BMIs) has spurred research into optimally choosing the input signal source for a desired application. The signals with highest bandwidth—single neuron action potentials, or spikes—typically are difficult to record for more than a few years after implantation of intracortical electrodes. Fortunately, field potentials recorded within the cortex (local field potentials, LFPs), at its surface (electrocorticograms, ECoG) and at the dural surface (epidural, EFPs) have also been shown to contain significant information about movement. However, the relative performance of these signals has not yet been directly compared. Furthermore, while it is widely postulated, it has not yet been demonstrated that these field potential signals are more durable than spike recordings. The aim of this study was to address both of these questions. We assessed the offline decoding performance of EFPs, LFPs, and spikes, recorded sequentially, in primary motor cortex (M1) in terms of their ability to decode the target of reaching movements, as well as the endpoint trajectory. We also examined the decoding performance of LFPs on electrodes that are not recording spikes, compared with the performance when they did record spikes. Spikes were still present on some of the other electrodes throughout this study. We showed that LFPs performed nearly as well as spikes in decoding velocity, and slightly worse in decoding position and in target classification. EFP performance was slightly inferior to that reported for ECoG in humans. We also provided evidence demonstrating that movement-related information in the LFP remains high regardless of the ability to record spikes concurrently on the same electrodes. This is the first study to provide evidence that LFPs retain information about movement in the absence of spikes on the same electrodes. These results suggest that LFPs may indeed remain informative after spike recordings are lost, thereby providing a robust, accurate signal source for BMIs.
登录
查看更多内容
影响因子：
4
作者：
Kubánek J;Miller KJ;Ojemann JG;Wolpaw JR;Schalk G
通讯作者：
Schalk G
DOI：
10.1523/jneurosci.2041-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Manning JR;Jacobs J;Fried I;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
5.3
作者：
Miller, K. J.;Zanos, S.;Ojemann, J. G.
通讯作者：
Ojemann, J. G.
影响因子：
2.5
作者：
Flint, Robert D.;Ethier, Christian;Slutzky, Marc W.
通讯作者：
Slutzky, Marc W.
影响因子：
5.3
作者：
Miller, Kai J.;Leuthardt, Eric C.;Ojemann, Jeffrey G.
通讯作者：
Ojemann, Jeffrey G.