Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover.
Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover.
复制标题
DOI：
10.3390/v13020262
复制
发表时间：
2021-02-08
期刊：
影响因子：
--
通讯作者：
Subbiah M
中科院分区：
文献类型：
--
作者：
Kuchipudi SV;Nelli RK;Gontu A;Satyakumar R;Surendran Nair M;Subbiah M
新出现的病毒性疾病是对全球健康的主要威胁，近三分之二的新出现的人类传染病是人畜共患病。大多数人类流行病和大流行病都是由野生哺乳动物的病毒溢出引起的。感染人类和各种动物的病毒在历史上曾造成毁灭性的流行病和大流行病。对病毒出现和人畜共患病溢出的机制仍然缺乏深入的了解。受体是宿主对病毒易感性的主要决定因素。共享支持多种病毒结合的宿主细胞受体的动物物种可以在病毒溢出和新病毒及其变体的出现中发挥关键作用。唾液酸（SA）与糖蛋白和神经节苷脂连接，作为几种人类和动物病毒的受体。特别是，流感和冠状病毒，代表两个最重要的人畜共患威胁，使用SA作为细胞进入受体。这是一个全面的审查，我们目前的知识SA受体分布在动物物种和病毒的范围内，使用SA作为受体。SA受体嗜性和预测的对病毒的天然易感性可以为家畜和野生动物的靶向监测提供信息，以防止未来出现人畜共患病病毒。
Emerging viral diseases are a major threat to global health, and nearly two-thirds of emerging human infectious diseases are zoonotic. Most of the human epidemics and pandemics were caused by the spillover of viruses from wild mammals. Viruses that infect humans and a wide range of animals have historically caused devastating epidemics and pandemics. An in-depth understanding of the mechanisms of viral emergence and zoonotic spillover is still lacking. Receptors are major determinants of host susceptibility to viruses. Animal species sharing host cell receptors that support the binding of multiple viruses can play a key role in virus spillover and the emergence of novel viruses and their variants. Sialic acids (SAs), which are linked to glycoproteins and ganglioside serve as receptors for several human and animal viruses. In particular, influenza and coronaviruses, which represent two of the most important zoonotic threats, use SAs as cellular entry receptors. This is a comprehensive review of our current knowledge of SA receptor distribution among animal species and the range of viruses that use SAs as receptors. SA receptor tropism and the predicted natural susceptibility to viruses can inform targeted surveillance of domestic and wild animals to prevent the future emergence of zoonotic viruses.
登录
查看更多内容
影响因子：
3.7
作者：
Bieringer M;Han JW;Kendl S;Khosravi M;Plattet P;Schneider-Schaulies J
通讯作者：
Schneider-Schaulies J
影响因子：
64.8
作者：
BLIX, FG;GOTTSCHALK, A;KLENK, E
通讯作者：
KLENK, E
DOI：
10.1074/jbc.m110.115998
发表时间：
2010-10-29
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bateman AC;Karamanska R;Busch MG;Dell A;Olsen CW;Haslam SM
通讯作者：
Haslam SM
DOI：
10.1007/978-3-319-92373-4_8
发表时间：
2018-01-01
期刊：
CONNECTIONS BETWEEN ECOLOGY AND INFECTIOUS DISEASE
影响因子：
--
作者：
Alexander, Kathleen A.;Carlson, Colin J.;Blackburn, Jason K.
通讯作者：
Blackburn, Jason K.
影响因子：
4.4
作者：
Costa T;Chaves AJ;Valle R;Darji A;van Riel D;Kuiken T;Majó N;Ramis A
通讯作者：
Ramis A